503-74-2
503-74-2
Chemical Structure
Isovaleric acid
- CAS No.: 503-74-2
- Formula:C5H10O2
- Molecular Weight:102.13
IUPAC Name: 3-methylbutanoic acid
InChIKey: GWYFCOCPABKNJV-UHFFFAOYSA-N
SMILES: CC(C)CC(O)=O
Biological Activity: Isovaleric acid is an oral active short-chain fatty acid that inhibits osteoclast differentiation by stimulating AMPK phosphorylation and promotes colonic smooth muscle relaxation by activating the cAMP/PKA pathway. Isovaleric acid can be used in research on skeletal diseases (such as osteoporosis) and intestinal disorders[1][2][3][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Isovaleric acid | 97.0% | Isovaleric acid is an oral active short-chain fatty acid that inhibits osteoclast differentiation by stimulating AMPK phosphorylation and promotes colonic smooth muscle relaxation by activating the cAMP/PKA pathway. Isovaleric acid can be used in research on skeletal diseases (such as osteoporosis) and intestinal disorders. | ||||||||||||||||||||
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Isovaleric acid (Standard) | 99.81% | Isovaleric acid (Standard) is the analytical standard of Isovaleric acid. This product is intended for research and analytical applications. Isovaleric acid is an oral active short-chain fatty acid that inhibits osteoclast differentiation by stimulating AMPK phosphorylation and promotes colonic smooth muscle relaxation by activating the cAMP/PKA pathway. Isovaleric acid can be used in research on skeletal diseases (such as osteoporosis) and intestinal disorders. | ||||||||||||||||||||
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Isovaleric acid-d9 | 99.27% | Isovaleric acid-d9 is the deuterium labeled Isovaleric acid. Isovaleric acid is a natural fatty acid and known to effect on neonatal death and possible Jamaican vomiting sickness in human. | ||||||||||||||||||||
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Isovaleric acid-d2 | 99.49% | Isovaleric acid-d2 is the deuterium labeled Isovaleric acid. Isovaleric acid is a natural fatty acid and known to effect on neonatal death and possible Jamaican vomiting sickness in human. | ||||||||||||||||||||
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Isovaleric acid-13C | 99.0% | Isovaleric acid-13C is the 13C labeled Isovaleric acid. Isovaleric acid is a natural fatty acid and known to effect on neonatal death and possible Jamaican vomiting sickness in human. | ||||||||||||||||||||
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3-Hydroxybutyric acid (Standard) | 97.37% | 3-Hydroxybutyric acid (Standard) is the analytical standard of 3-Hydroxybutyric acid. This product is intended for research and analytical applications. 3-Hydroxybutyric acid (β-Hydroxybutyric acid) is a metabolite that is elevated in type I diabetes. 3-Hydroxybutyric acid can modulate the properties of membrane lipids. | ||||||||||||||||||||
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L-Valine-d8 | 99.91% | L-Valine-d8 is a deuterated form of L-Valine (HY-N0717). L-Valine ((S)-Valine) is a nonlinear semiorganic material. L-Valine causes lipid peroxidation and accumulation of malondialdehyde (MDA), exhibits inhibitory activity against cyanobacteria. L-Valine inhibits multidrug-resistant bacteria through activation of PI3K/Akt signaling pathway and inhibition of arginase. | ||||||||||||||||||||
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D-Valine-d8 | 99.09% | D-Valine-d8 is the deuterium labeled D-Valine. D-Valine is the enantiomer of L-Valine (HY-N0717). L-Valine is one of 20 proteinogenic amino acids. L-Valine is an essential amino acid. | ||||||||||||||||||||
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L-Valine-13C5,15N,d8 | L-Valine-13C5,15N,d8 ((S)-Valine-13C5,15N,d8) is the deuterium, 13C-, and 15N-labeled L-Valine (HY-N0717). L-Valine ((S)-Valine) is a nonlinear semiorganic material. L-Valine causes lipid peroxidation and accumulation of malondialdehyde (MDA), exhibits inhibitory activity against cyanobacteria. L-Valine inhibits multidrug-resistant bacteria through activation of PI3K/Akt signaling pathway and inhibition of arginase. | |||||||||||||||||||||
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DL-2-Methylbutyric acid-d9 | 98.82% | DL-2-Methylbutyric acid-d9 is the deuterium labeled DL-2-Methylbutyric acid. | ||||||||||||||||||||
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3-Aminobutanoic acid | 98.0% | 3-Aminobutanoic acid is a β-amino acid. 3-Aminobutanoic acid can protect plant against a challenge infection with P. infestans. 3-Aminobutanoic acid has various levels of susceptibility for the pathogen. | ||||||||||||||||||||
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3-Methylvaleric Acid | 99.99% | 3-Methylvaleric Acid is a branched alkanoic acid. 3-Methylvaleric Acid can be utilized by Pseudomonas citronettotis as a sole carbon source for its growth. 3-Methylvaleric Acid derivatives exhibit anti-hyperalgesic and anticonvulsant activities. | ||||||||||||||||||||
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3-Amino-4-methylpentanoic acid (Standard) | ≥98% | 3-Amino-4-methylpentanoic acid is a β amino acid and positional isomer of L-leucine which is naturally produced in humans via the metabolism of L-leucine by the enzyme leucine 2,3-aminomutase. 3-Amino-4-methylpentanoic acid is also a metabolite produced by Torulaspora delbrueckii and can be used in the research of wine fermentation. | ||||||||||||||||||||
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DL-Valine-d8 | 99.96% | DL-Valine-d8 is the deuterium labeled DL-Valine. | ||||||||||||||||||||
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4-Methylpentanoic acid | 99.15% | 4-Methylpentanoic acid (Isocaproic Acid) is a short-chain fatty acid and a metabolite of 20 α-hydroxycholesterol (HY-12316) that can be detected in feces. The concentration of 4-Methylpentanoic acid is closely associated with several diseases, such as depression. 4-Methylpentanoic acid is also applicable to studies on cholesterol metabolism. |
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4-Methylpentanoic acid-d11 | 99.28% | 4-Methylpentanoic acid-d11 (Isocaproic Acid-d11) is the deuterium labeled 4-Methylpentanoic acid. 4-Methylpentanoic acid is a short-chain fatty acid and a metabolite of 20 α-hydroxycholesterol (HY-12316) that can be detected in feces. The concentration of 4-Methylpentanoic acid is closely associated with several diseases, such as depression. 4-Methylpentanoic acid is also applicable to studies on cholesterol metabolism. |
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(S)-3-Hydroxybutanoic acid | 97.0% | (S)-3-Hydroxybutanoic acid is a metabolite and a disease marker of depression. 3-Hydroxybutyric acid is synthesized in the liver from acetyl-CoA, and can be used as an energy source by the brain when blood glucose is low. | ||||||||||||||||||||
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(R)-3-Hydroxybutanoic acid | 97.65% | (R)-3-Hydroxybutanoic acid is a metabolite, and converted from acetoacetic acid catalyzed by 3-hydroxybutyrate dehydrogenase. (R)-3-Hydroxybutanoic acid has applications as a nutrition source and as a precursor for vitamins, antibiotics and pheromones. | ||||||||||||||||||||
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6-Methylheptanoic acid | 95.76% | 6-Methylheptanoic acid is an ester product. | ||||||||||||||||||||
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Pivalic acid-d9 | 98.00% | Pivalic acid-d9 is the deuterium labeled Pivalic acid. | ||||||||||||||||||||
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References
- [1]. Ackman RG, et al. Birthweights in the Faroe Islands: possible role of isovaleric acid. J Intern Med. 1989 Feb;225(2):73-5. [Content Brief]
- [2]. Ribeiro C A J, et al. Isovaleric acid reduces Na+, K+-ATPase activity in synaptic membranes from cerebral cortex of young rats[J]. Cellular and molecular neurobiology, 2007, 27: 529-540. [Content Brief]
- [3]. Cho K M, et al. Isovaleric acid ameliorates ovariectomy‐induced osteoporosis by inhibiting osteoclast differentiation[J]. Journal of Cellular and Molecular Medicine, 2021, 25(9): 4287-4297. [Content Brief]
- [4]. Blakeney BA, et al. Branched Short-Chain Fatty Acid Isovaleric Acid Causes Colonic Smooth Muscle Relaxation via cAMP/PKA Pathway. Dig Dis Sci. 2019 May;64(5):1171-1181. [Content Brief]
