503-74-2
503-74-2
Chemical Structure
Isovaleric acid
- CAS No.: 503-74-2
- Formula:C5H10O2
- Molecular Weight:102.13
IUPAC Name: 3-methylbutanoic acid
InChIKey: GWYFCOCPABKNJV-UHFFFAOYSA-N
SMILES: CC(C)CC(O)=O
Biological Activity: Isovaleric acid is an oral active short-chain fatty acid that inhibits osteoclast differentiation by stimulating AMPK phosphorylation and promotes colonic smooth muscle relaxation by activating the cAMP/PKA pathway. Isovaleric acid can be used in research on skeletal diseases (such as osteoporosis) and intestinal disorders[1][2][3][4].
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Isovaleric acid | 97.0% | Isovaleric acid is an oral active short-chain fatty acid that inhibits osteoclast differentiation by stimulating AMPK phosphorylation and promotes colonic smooth muscle relaxation by activating the cAMP/PKA pathway. Isovaleric acid can be used in research on skeletal diseases (such as osteoporosis) and intestinal disorders. | ||||||||||||||||||||
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Isovaleric acid (Standard) | 99.81% | Isovaleric acid (Standard) is the analytical standard of Isovaleric acid. This product is intended for research and analytical applications. Isovaleric acid is an oral active short-chain fatty acid that inhibits osteoclast differentiation by stimulating AMPK phosphorylation and promotes colonic smooth muscle relaxation by activating the cAMP/PKA pathway. Isovaleric acid can be used in research on skeletal diseases (such as osteoporosis) and intestinal disorders. | ||||||||||||||||||||
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Isovaleric acid-d9 | 99.27% | Isovaleric acid-d9 is the deuterium labeled Isovaleric acid. Isovaleric acid is a natural fatty acid and known to effect on neonatal death and possible Jamaican vomiting sickness in human. | ||||||||||||||||||||
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Isovaleric acid-d2 | 99.49% | Isovaleric acid-d2 is the deuterium labeled Isovaleric acid. Isovaleric acid is a natural fatty acid and known to effect on neonatal death and possible Jamaican vomiting sickness in human. | ||||||||||||||||||||
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Isovaleric acid-13C | 99.0% | Isovaleric acid-13C is the 13C labeled Isovaleric acid. Isovaleric acid is a natural fatty acid and known to effect on neonatal death and possible Jamaican vomiting sickness in human. | ||||||||||||||||||||
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References
- [1]. Ackman RG, et al. Birthweights in the Faroe Islands: possible role of isovaleric acid. J Intern Med. 1989 Feb;225(2):73-5. [Content Brief]
- [2]. Ribeiro C A J, et al. Isovaleric acid reduces Na+, K+-ATPase activity in synaptic membranes from cerebral cortex of young rats[J]. Cellular and molecular neurobiology, 2007, 27: 529-540. [Content Brief]
- [3]. Cho K M, et al. Isovaleric acid ameliorates ovariectomy‐induced osteoporosis by inhibiting osteoclast differentiation[J]. Journal of Cellular and Molecular Medicine, 2021, 25(9): 4287-4297. [Content Brief]
- [4]. Blakeney BA, et al. Branched Short-Chain Fatty Acid Isovaleric Acid Causes Colonic Smooth Muscle Relaxation via cAMP/PKA Pathway. Dig Dis Sci. 2019 May;64(5):1171-1181. [Content Brief]
