515-49-1
Chemical Structure
Sulfathiourea
- CAS No.: 515-49-1
- Formula:C7H9N3O2S2
- Molecular Weight:231.29
IUPAC Name: 4-amino-N-carbamothioylbenzenesulfonamide
InChIKey: UEMLYRZWLVXWRU-UHFFFAOYSA-N
SMILES: O=S(=O)(NC(=S)N)C1=CC=C(N)C=C1
Biological Activity: Sulfathiourea is an inhibitor of Pneumocystis carinii dihydropteroate synthetase (dihydropteroate synthetase), with an IC50 of 0.022 μM and a Ki of 16.5 nM. Sulfathiourea blocks folate biosynthesis by inhibiting the enzyme that links 7,8-dihydro-6-hydroxymethylpterin pyrophosphate with p-aminobenzoic acid to form dihydropteroate. Sulfathiourea can be used in research related to *Pneumocystis carinii* pneumonia[1].
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Sulfathiourea | Sulfathiourea is an inhibitor of Pneumocystis carinii dihydropteroate synthetase (dihydropteroate synthetase), with an IC50 of 0.022 μM and a Ki of 16.5 nM. Sulfathiourea blocks folate biosynthesis by inhibiting the enzyme that links 7,8-dihydro-6-hydroxymethylpterin pyrophosphate with p-aminobenzoic acid to form dihydropteroate. Sulfathiourea can be used in research related to *Pneumocystis carinii* pneumonia. | |||||||||||||||||||||
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Keywords
