520-63-8
Chemical Structure
Heliotridine
Synonym(s): (+)-Heliotridine
- CAS No.: 520-63-8
- Formula:C8H13NO2
- Molecular Weight:155.19
InChIKey: HJSJELVDQOXCHO-JGVFFNPUSA-N
SMILES: OCC1=CCN2[C@@]1([H])[C@@H](O)CC2
Biological Activity: Heliotridine ((+)-Heliotridine) is a monoesters-type necine base of pyrrolizidine alkaloid with genotoxic and antibacterial properties. Heliotridine can be isolated from the aerial parts of Heliotropium ellipticum, Heliotropium circinatum and other Heliotropium species (Boraginaceae). Heliotridine shows high tolerance in normal human hepatocytes (EC50 > 400 μM). Mediated by the organic cation transporter OCT1, Heliotridine exhibits in vitro growth inhibition and weak antibacterial activity against Drechslera tetramera. Heliotridine can be used in infection-related studies of specific pathogenic bacteria[1][2][3].
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Heliotridine | Heliotridine ((+)-Heliotridine) is a monoesters-type necine base of pyrrolizidine alkaloid with genotoxic and antibacterial properties. Heliotridine can be isolated from the aerial parts of Heliotropium ellipticum, Heliotropium circinatum and other Heliotropium species (Boraginaceae). Heliotridine shows high tolerance in normal human hepatocytes (EC50 > 400 μM). Mediated by the organic cation transporter OCT1, Heliotridine exhibits in vitro growth inhibition and weak antibacterial activity against Drechslera tetramera. Heliotridine can be used in infection-related studies of specific pathogenic bacteria. | |||||||||||||||||||||
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References
- [1]. JAIN S C, et al. Antimicrobial activity of pyrrolizidine alkaloids from Heliotropium ellipticum[J]. Chemical and pharmaceutical bulletin, 1987, 35(8): 3487-3489.
- [2]. Al-Suhail N, et al. Isolation of Pyrrolizidine Alkaloids from a Newly Recorded Heliotropium Species in Southern Basrah and Evaluation of its Anticancer Potential[J]. Eurasian Journal of Oncology, 2025, 13(3).
- [3]. Haas M. Investigation of the hepatotoxic potency of selected genotoxic pyrrolizidine alkaloids and the significance of the DNA damage response[D]. Rheinland-Pfälzische Technische Universität Kaiserslautern-Landau, 2025.
