52497-36-6
Chemical Structure
Dihydrokainic acid
- CAS No.: 52497-36-6
- Formula:C10H17NO4
- Molecular Weight:215.25
IUPAC Name: (2S,3S,4R)-3-(carboxymethyl)-4-isopropylpyrrolidine-2-carboxylic acid
InChIKey: JQPDCKOQOOQUSC-OOZYFLPDSA-N
SMILES: O=C(O)C[C@@H]1[C@@H](C(O)=O)NC[C@@H]1C(C)C
Biological Activity: Dihydrokainic acid is a glutamate transporters (especially GLT1) inhibitor. Dihydrokainic acid targets GLT1 with high affinity, effectively inhibiting its transport function. Dihydrokainic acid exerts its effect by inhibiting the uptake of glutamate, leading to an increase in extracellular glutamate concentration, thereby affecting neuronal excitability and neurotransmission. Dihydrokainic acid is mainly applied in the field of neuroscience for research on glutamate-related neural functions, epilepsy, learning, and memory[1][2][3][4][5].
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Dihydrokainic acid | 99.0% | Dihydrokainic acid is a glutamate transporters (especially GLT1) inhibitor. Dihydrokainic acid targets GLT1 with high affinity, effectively inhibiting its transport function. Dihydrokainic acid exerts its effect by inhibiting the uptake of glutamate, leading to an increase in extracellular glutamate concentration, thereby affecting neuronal excitability and neurotransmission. Dihydrokainic acid is mainly applied in the field of neuroscience for research on glutamate-related neural functions, epilepsy, learning, and memory. | ||||||||||||||||||||
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Dihydrokainic acid (Standard) | ≥98% | Dihydrokainic acid (Standard) is the analytical standard of Dihydrokainic acid. This product is intended for research and analytical applications. Dihydrokainic acid (DHK) is a glutamate transporter GLT1 (EAAT2) inhibitor. Dihydrokainic acid impairs novel object recognition (NOR) memory performance in mice. Dihydrokainic acid also shows epileptogenic effects. | ||||||||||||||||||||
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- [1]. Lehmann A, et al. Dihydrokainic acid affects extracellular taurine and phosphoethanolamine levels in the hippocampus. Neuroscience Letters, 1983, 38(1): 67-72.
- [2]. Bouazzaoui M, et al. Kainic acid, AMPA, and dihydrokainic acid effect on uptake and efflux of D-[3H] aspartic acid in cerebellar slices. Neurochem Res. 1996 Dec;21(12):1527-33. [Content Brief]
- [3]. Butcher SP, et al. On the epileptogenic effects of kainic acid and dihydrokainic acid in the dentate gyrus of the rat. Neuropharmacology. 1988 Apr;27(4):375-81. [Content Brief]
- [4]. Tian SW, et al. Glutamate transporter GLT1 inhibitor dihydrokainic acid impairs novel object recognition memory performance in mice. Physiol Behav. 2019 Feb 1;199:28-32. [Content Brief]
- [5]. Muñoz M D, et al. Effects of dihydrokainic acid of extracellular amino acids and neuronal excitability in the in vivo rat hippocampus. Neuropharmacology, 1987, 26(1): 1-8.
