550-10-7
550-10-7
Chemical Structure
Hydrocotarnine
- CAS No.: 550-10-7
- Formula:C12H15NO3
- Molecular Weight:221.25
IUPAC Name: 4-methoxy-6-methyl-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinoline
InChIKey: XXANNZJIZQTCBP-UHFFFAOYSA-N
SMILES: CN1CCC2=CC3=C(C(=C2C1)OC)OCO3
Biological Activity: Hydrocotarnine is a Cbl inhibitor, and results in inflammasome-mediated IL-18 secretion in colitis. Hydrocotarnine increases expression of GLUT1 and cellular glucose uptake in glycolytic metabolism. Hydrocotarnine acts as an agent that provides analgesic effect in cancer research[1][2][3].
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Hydrocotarnine | 99.70% | Hydrocotarnine is a Cbl inhibitor, and results in inflammasome-mediated IL-18 secretion in colitis. Hydrocotarnine increases expression of GLUT1 and cellular glucose uptake in glycolytic metabolism. Hydrocotarnine acts as an agent that provides analgesic effect in cancer research. | ||||||||||||||||||||
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Lophophorine | Lophophorine is a natural alkaloid compound. | |||||||||||||||||||||
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Apiole | Apiole is an anti-tumor agent that induces apoptosis and inhibits human colon cancer cells by inducing G0/G1 cell cycle arrest. Apiole also significantly inhibited colon tumor development in an in vivo mouse xenograft model. | |||||||||||||||||||||
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(±)-Pellotine hydrochloride | (±)-Pellotine hydrochloride (Compound 2) is an alkaloid, which is found in L. diffusa and L. fricii. (±)-Pellotine hydrochloride decreases locomotor activity and the amount of rapid eye movement (REM) sleep in mice. | |||||||||||||||||||||
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Pellotine | Pellotine is an alkaloid that can be isolated from Lophophora. Pellotine is the inverse agonist for 5-HT7 receptor with an EC50 of 291 nM. Pellotine exhibits good affinity to 5-HT1DR and 5-HT6R with Ki of 117 nM and 170 nM. Pellotine reduces intracellular cAMP levels, thereby reducing neuronal excitability and neurotransmitter release. | |||||||||||||||||||||
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Apiol analog-1 | Apiol analog-1 (Compound 2b) is an analog of Apiol (HY-135217). Apiole is an anti-tumor agent that induces apoptosis and inhibits human colon cancer cells by inducing G0/G1 cell cycle arrest. Apiole also significantly inhibited colon tumor development in an in vivo mouse xenograft model. | |||||||||||||||||||||
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Hydrastinine hydrochloride | 99.41% | Hydrastinine hydrochloride is a major alkaloid constituent in goldenseal (Hydrastis canadensis). Hydrastinine hydrochloride can be used as a haemostatic agent. | ||||||||||||||||||||
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N-Methylcorydaldine | N-Methylcorydaldine, an alkaloid, shows promising anti-secretory activity. | |||||||||||||||||||||
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Hydrocotarnine hydrobromide | Hydrocotarnine (hydrobromide) is a Alkaloids product that can be isolated from From Vaccinium macrocarpon. | |||||||||||||||||||||
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Dill apiole | 99.18% | Dill apiole is an aromatic ether, which is an important aroma component in herbs and spices such as dill (Anethum graveolens), parsley (Petroselinum crispum) and basil (Perilla frutescens). Dill apiole exhibits antimicrobial activity against Aspergillus parasiticus and Aedes aegypti. | ||||||||||||||||||||
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Carnegine hydrochloride | Carnegine hydrochloride is a fungicide with broad-spectrum antibacterial activity, as well as a stereoselective inhibitor of MAO-A/MAO-B. Carnegine hydrochloride has no antioxidant activity and does not affect cerebral PDE, but it antagonizes the chronotropic effects of adrenaline and noradrenaline at low concentrations and induces tolerance in *Drosophila melanogaster*. Carnegine hydrochloride stimulates respiration, exerts mild spasmolytic and hypotensive effects, inhibits cancer cell respiration, and exhibits central nervous system excitatory toxicity and negative chronotropic effects on the cardiovascular system. | |||||||||||||||||||||
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References
- [1]. Chung IC, et al. Src-family kinase-Cbl axis negatively regulates NLRP3 inflammasome activation. Cell Death Dis. 2018 Oct 31;9(11):1109. [Content Brief]
- [2]. Lin HC, et al. Cbl Negatively Regulates NLRP3 Inflammasome Activation through GLUT1-Dependent Glycolysis Inhibition. Int J Mol Sci. 2020 Jul 19;21(14):5104. [Content Brief]
- [3]. Kim KU, et al. DITMD-induced mitotic defects and apoptosis in tumor cells by blocking the polo-box domain-dependent functions of polo-like kinase 1. Eur J Pharmacol. 2019 Mar 15;847:113-122. [Content Brief]
