5575-21-3
5575-21-3
Chemical Structure
Cefalonium
- CAS No.: 5575-21-3
- Formula:C20H18N4O5S2
- Molecular Weight:458.51
IUPAC Name: (6R,7R)-3-((4-carbamoylpyridin-1-ium-1-yl)methyl)-8-oxo-7-(2-(thiophen-2-yl)acetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
InChIKey: FMZXNVLFJHCSAF-DNVCBOLYSA-N
SMILES: O=C(N[C@H]1[C@@]2([H])SCC(C[N+]3=CC=C(C(N)=O)C=C3)=C(C([O-])=O)N2C1=O)CC4=CC=CS4
Biological Activity: Cefalonium is a first-generation cephalosporin bactericidal antimicrobial agent. Cefalonium can be used in studies related to bovine mastitis, Staphylococcus aureus-induced mastitis and intramammary infections[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Cefalonium | 98.85% | Cefalonium is a first-generation cephalosporin bactericidal antimicrobial agent. Cefalonium can be used in studies related to bovine mastitis, Staphylococcus aureus-induced mastitis and intramammary infections. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Cefalonium (Standard) | ≥98% | Cefalonium (Standard) is the analytical standard of Cefalonium (HY-B1252). This product is intended for research and analytical applications. Cefalonium is a first-generation cephalosporin bactericidal antimicrobial agent. Cefalonium can be used in studies related to bovine mastitis, Staphylococcus aureus-induced mastitis and intramammary infections. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
CENTA | 98% | CENTA is a colorimetric cephalosporin substrate for β-lactamases. Upon hydrolysis by β-lacatamases, CENTA turns from light yellow to chrome yellow, which can be quantified by colorimetric detection at 405 nm as a measure of β-lactamase activity. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Cefsulodin | Cefsulodin (SCE-129) showed potent activity against Pseudomonas aeruginosa and strains susceptible to penicillin and gentamicin, with effectiveness comparable to that of gentamicin and debendazole. However, its effectiveness was diminished against penicillin-resistant strains of P. aeruginosa, particularly strains that were also resistant to gentamicin. For P. aeruginosa maltofila, SCE-129 showed similar minimum inhibitory concentrations to penicillin, gentamicin, and debendazole. Pseudomonas cepacia strains generally showed moderate resistance to SCE-129 and penicillin, and high resistance to gentamicin and debendazole. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Cefsulodin sodium (Standard) | ≥98% | Cefsulodin (sodium) (Standard) is the analytical standard of Cefsulodin (sodium). This product is intended for research and analytical applications. Cefsulodin (SCE-129) sodium is a third generation β lactam antibiotic and member of the cephems subgroup of antibiotics. Cefsulodin sodium inhibits cell wall synthesis by competitively inhibiting penicillin binding protein (PBP) cross-linking and transpeptidation of peptidogly. Cefsulodin sodium is a potent tyrosine phosphatase inhibitor against mPTPB, a virulent phosphatase from Mycobacterium tuberculosis, with an IC50 value of 16 μM. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Cephalosporin C analog-1 | Cephalosporin C analog-1 is an analogue of Cephalosporin C (HY-B1299). Cephalosporin C has weak resistance to Gram-positive and negative bacteria, is stable to penicillinase, and can be broken down by cephalosporin enzyme. Hydrolysis and removal of side chains to obtain 7-amino-cefenoic acid (7-ACA) is an important raw material for the preparation of semi-synthetic cephalosporin. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Cefalonium hydrate | Cefalonium hydrate is a first-generation cephalosporin bactericidal antimicrobial agent. Cefalonium hydrate can be used in studies related to bovine mastitis, Staphylococcus aureus-induced mastitis and intramammary infections. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Cefalonium dihydrate | Cefalonium dihydrate is a first-generation cephalosporin bactericidal antimicrobial agent. Cefalonium dihydrate can be used in studies related to bovine mastitis, Staphylococcus aureus-induced mastitis and intramammary infections. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Cephalothin (Standard) | ≥98% | Cephalothin (Cephalotin) (Standard) is the analytical standard of Cephalothin (HY-B1275A). This product is intended for research and analytical applications. Cephalothin is a semi-synthetic cephalosporin antibiotic and beta-lactam antibiotic. Cephalothin inhibits class C β-lactamase AmpC, with an Ki of 0.32 µM. Cephalothin binds to penicillin-binding proteins, interfering with the cross-linking of peptidoglycan in the cell wall and thus hindering the normal synthesis of the bacterial cell wall. Cephalothin shows antibacterial activity against a variety of bacteria. Cephalothin can be used in hematological and nephrotoxicity studies. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Cephaloridine | Cephaloridine is a broad-spectrum antibacterial antibiotic. Cephaloridine has certain dose-related nephrotoxicity. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Cephaloridine hydrate (Standard) | ≥98% | Cephaloridine hydrate (Standard) is the analytical standard of Cephaloridine hydrate (HY-B2072A). This product is intended for research and analytical applications. Cephaloridine hydrate is a broad-spectrum antibacterial antibiotic. Cephaloridine has certain dose-related nephrotoxicity. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Cefetrizole | Ceftezole is an α-Glucosidase inhibitor with an IC50 and a Ki of 2.1 μM and 0.578 μM, respectively. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. Harada K, et al. Assessment of the Usefulness of Cefapirin and Cefalonium Disks for Susceptibility Testing of Staphylococcus aureus Isolates from Bovine Mastitis. Antibiotics (Basel). 2020 Apr 21;9(4):197. [Content Brief]
- [2]. Demon D, et al. The intramammary efficacy of first generation cephalosporins against Staphylococcus aureus mastitis in mice. Veterinary microbiology. 2012 Nov 09;160(1-2):141-50. [Content Brief]
- [3]. Berry EA, et al. Effect of an intramammary teat seal and dry cow antibiotic in relation to dry period length on postpartum mastitis. Journal of dairy science. 2007 Feb;90(2):760-5. [Content Brief]
