565-20-8
565-20-8
Chemical Structure
N-Acetyl dapsone
Synonym(s): MADDS; Monoacetyldapsone
- CAS No.: 565-20-8
- Formula:C14H14N2O3S
- Molecular Weight:290.34
IUPAC Name: N-(4-((4-aminophenyl)sulfonyl)phenyl)acetamide
InChIKey: WDOCBIHNYYQINH-UHFFFAOYSA-N
SMILES: CC(NC1=CC=C(S(=O)(C2=CC=C(N)C=C2)=O)C=C1)=O
Biological Activity: N-Acetyl dapsone (MADDS) is the major metabolite of Dapsone (HY-B0688). Dapsone is an orally active and blood-brain penetrant sulfonamide antibiotic with bacteriostatic, antimycobacterial and antiprotozoal activities[1][2].
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N-Acetyl dapsone | N-Acetyl dapsone (MADDS) is the major metabolite of Dapsone (HY-B0688). Dapsone is an orally active and blood-brain penetrant sulfonamide antibiotic with bacteriostatic, antimycobacterial and antiprotozoal activities. | |||||||||||||||||||||
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N-Acetyl dapsone-d4-1 | N-acetyl Dapsone-d4-1 is the deuterium labeled N-acetyl Dapsone, which is a metabolite of Dapsone. | |||||||||||||||||||||
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N-Acetyl dapsone-d8 | N-Acetyl Dapsone-d8 is the deuterium labeled N-Acetyl Dapsone. | |||||||||||||||||||||
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N-Acetyl dapsone-d4 | 98.0% | N-acetyl Dapsone-d4 is the deuterium labeled N-acetyl Dapsone, which is a metabolite of Dapsone. | ||||||||||||||||||||
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References
- [1]. Tanaka K, et al. Mutagenicity of N-acetyl and N,N'-diacetyl derivatives of 3 aromatic amines used as epoxy-resin hardeners. Mutat Res. 1985 May-Jun;143(1-2):11-5. [Content Brief]
- [2]. Bonde S L, et al. Simultaneous determination of dapsone and its major metabolite N-Acetyl Dapsone by LC-MS/MS method. Int. J. Pharm. Pharm. Sci, 2013, 5: 441-446.
