57360-69-7
Chemical Structure
MTT Formazan
- CAS No.: 57360-69-7
- Formula:C18H17N5S
- Molecular Weight:335.43
IUPAC Name: (E,E)-5-(4,5-dimethylthiazol-2-yl)-1,3-diphenylformazan
InChIKey: YTQNSFTVNHYUBQ-CMAJWFLJSA-N
SMILES: CC1=C(C)N=C(N/N=C(C2=CC=CC=C2)/N=N/C3=CC=CC=C3)S1
Biological Activity: MTT Formazan is a purple water-insoluble product formed by the reduction of yellow soluble MTT by succinate dehydrogenase in the mitochondria of viable cells. The amount of MTT Formazan produced is proportional to cellular metabolic activity, and it can serve as an indicator for evaluating cell viability and proliferation. MTT Formazan exhibits solvent-dependent solubility properties, and its absorbance value can be measured by spectrophotometry to reflect cellular status. MTT Formazan also supports the assessment of cell viability in bacterial MTT assays. MTT Formazan can be used in photoacoustic microscopy to enhance the imaging effect of viable cells, especially in applications in the fields of three-dimensional cell culture and tissue engineering[1][2].
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MTT Formazan | 99.67% | MTT Formazan is a purple water-insoluble product formed by the reduction of yellow soluble MTT by succinate dehydrogenase in the mitochondria of viable cells. The amount of MTT Formazan produced is proportional to cellular metabolic activity, and it can serve as an indicator for evaluating cell viability and proliferation. MTT Formazan exhibits solvent-dependent solubility properties, and its absorbance value can be measured by spectrophotometry to reflect cellular status. MTT Formazan also supports the assessment of cell viability in bacterial MTT assays. MTT Formazan can be used in photoacoustic microscopy to enhance the imaging effect of viable cells, especially in applications in the fields of three-dimensional cell culture and tissue engineering. | ||||||||||||||||||||
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- [1]. Benov L, et al. Improved Formazan Dissolution for Bacterial MTT Assay. Microbiol Spectr. 2021;9(3):e0163721. [Content Brief]
- [2]. Gasque K C S, et al. Cell density and solvent are critical parameters affecting formazan evaluation in MTT assay[J]. Brazilian archives of Biology and Technology, 2014, 57: 381-385.
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