57760-36-8
Chemical Structure
Alborixin
- CAS No.: 57760-36-8
- Formula:C48H84O14
- Molecular Weight:885.17
InChIKey: WWDHGOLBPBWCNJ-GXXSWWTOSA-N
SMILES: O[C@@]1([C@]2(O[C@](CC2)([H])[C@H]([C@@]3(O[C@@H]([C@H](C[C@H]3C)C)C[C@]4(O[C@@](CC[C@@H]4C)([H])[C@@H](C)[C@H](O)C[C@@H]5O[C@]([C@H](C[C@H]5C)C)([H])[C@@H](C)C(O)=O)O)O)O)C)O[C@@](C[C@H]1C)([C@]6([H])O[C@H]([C@](O)(CC6)C)CC)C
Biological Activity: Alborixin is a polycyclic polyether ionophore Antibiotic. Alborixin is isolated from cultures of Streptomyces albus. Alborixin induces Autophagy via PTEN-mediated inhibition of the AKT pathway, thereby clearing Amyloid-β. Alborixin exhibits activity against Gram-positive bacteria and fungi. Alborixin can be used in the research of Alzheimer's disease[1][2].
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Alborixin | Alborixin is a polycyclic polyether ionophore Antibiotic. Alborixin is isolated from cultures of Streptomyces albus. Alborixin induces Autophagy via PTEN-mediated inhibition of the AKT pathway, thereby clearing Amyloid-β. Alborixin exhibits activity against Gram-positive bacteria and fungi. Alborixin can be used in the research of Alzheimer's disease. | |||||||||||||||||||||
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References
- [1]. Wani A, et al. Alborixin clears amyloid-β by inducing autophagy through PTEN-mediated inhibition of the AKT pathway. Autophagy. 2019;15(10):1810-1828. [Content Brief]
- [2]. Gachon P, et al. Alborixin, a new antibiotic ionophore: isolation, structure, physical and chemical properties. J Antibiot (Tokyo). 1976;29(6):603-610. [Content Brief]
