603-41-8
Chemical Structure
Desacetyl bisacodyl
- CAS No.: 603-41-8
- Formula:C18H15NO2
- Molecular Weight:277.32
IUPAC Name: 4,4'-(pyridin-2-ylmethylene)diphenol
InChIKey: LJROKJGQSPMTKB-UHFFFAOYSA-N
SMILES: OC1=CC=C(C(C2=CC=C(O)C=C2)C3=NC=CC=C3)C=C1
Biological Activity: Desacetyl bisacodyl is the active metabolite of Bisacodyl (HY-B0557) and induces mucosal COX signaling-dependent chloride secretion in the colorectal epithelium. Desacetyl bisacodyl induces biphasic changes in short-circuit current and tissue conductance after mucosal-side administration, and induces secretory responses in the mid colon, distal colon, and rectum. Desacetyl bisacodyl can be used for research on constipation[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Desacetyl bisacodyl | 99.52% | Desacetyl bisacodyl is the active metabolite of Bisacodyl (HY-B0557) and induces mucosal COX signaling-dependent chloride secretion in the colorectal epithelium. Desacetyl bisacodyl induces biphasic changes in short-circuit current and tissue conductance after mucosal-side administration, and induces secretory responses in the mid colon, distal colon, and rectum. Desacetyl bisacodyl can be used for research on constipation. | ||||||||||||||||||||
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Desacetyl bisacodyl (Standard) | ≥98% | Desacetyl bisacodyl (Standard) is the analytical standard of Desacetyl bisacodyl (HY-131637). This product is intended for research and analytical applications. Desacetyl bisacodyl is the active metabolite of Bisacodyl (HY-B0557) and induces mucosal COX signaling-dependent chloride secretion in the colorectal epithelium. Desacetyl bisacodyl induces biphasic changes in short-circuit current and tissue conductance after mucosal-side administration, and induces secretory responses in the mid colon, distal colon, and rectum. Desacetyl bisacodyl can be used for research on constipation. | ||||||||||||||||||||
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Desacetyl bisacodyl-d13 | Desacetyl bisacodyl-d13 is the deuterated-labeled Desacetyl bisacodyl (HY-131637). Desacetyl bisacodyl is the active metabolite of Bisacodyl (HY-B0557) and induces mucosal COX signaling-dependent chloride secretion in the colorectal epithelium. Desacetyl bisacodyl induces biphasic changes in short-circuit current and tissue conductance after mucosal-side administration, and induces secretory responses in the mid colon, distal colon, and rectum. Desacetyl bisacodyl can be used for research on constipation. | |||||||||||||||||||||
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Similarity Score 0.78
HY-W326021Phenolphthalol -
Similarity Score 0.71
HY-W101459Bisphenol E -
Similarity Score 0.71
HY-B0557Bisacodyl -
Similarity Score 0.68
HY-D0306Tris(4-aminophenyl)methane -
Similarity Score 0.66
HY-118407LY56110 -
Similarity Score 0.65
HY-W0142264,4'-Dihydroxybenzophenone -
Similarity Score 0.65
HY-B0544Sodium Picosulfate -
Similarity Score 0.64
HY-107793Picosulfate sodium salt hydrate -
Similarity Score 0.64
HY-W4825934-(Di(1H-pyrrol-2-yl)methyl)pyridine -
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References
- [1]. Fujita T, et al. Desacetyl bisacodyl-induced epithelial Cl⁻ secretion in rat colon and rectum. Biomedical Research, 2016, 37(1): 13-20.
- [2]. Zhu S S, et al. Discovery and confirmation of a novel chlorinated bisacodyl derivative illicitly added to a functional fruit and vegetable juice beverage. Journal of Food Composition and Analysis, 2026, 155: 109220.
- [3]. Hillestad B, et al. Intestinal handling of bisacodyl and picosulphate by everted sacs of the rat jejunum and stripped colon. Acta pharmacologica et toxicologica. 1982 Oct;51(4):388-94.
