604-59-1
604-59-1
Chemical Structure
Alpha-Naphthoflavone
- CAS. Nr.: 604-59-1
- Formula:C19H12O2
- Molecular Weight:272.30
IUPAC Name: 2-phenyl-4H-benzo[h]chromen-4-one
InChIKey: VFMMPHCGEFXGIP-UHFFFAOYSA-N
SMILES: O=C1C=C(C2=CC=CC=C2)OC3=C1C=CC4=CC=CC=C43
Biological Activity: Alpha-Naphthoflavone is an orally active flavonoid that is a potent, competitive inhibitor of aromatase with the IC50 and Ki values are 0.5 and 0.2 μM. Alpha-Naphthoflavone can inhibit cell proliferation and induce apoptosis[1][2][3][4].
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Alpha-Naphthoflavone | 99.76% | Alpha-Naphthoflavone is an orally active flavonoid that is a potent, competitive inhibitor of aromatase with the IC50 and Ki values are 0.5 and 0.2 μM. Alpha-Naphthoflavone can inhibit cell proliferation and induce apoptosis. | ||||||||||||||||||||
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Alpha-Naphthoflavone (Standard) | 99.44% | Alpha-Naphthoflavone (Standard) is the analytical standard of Alpha-Naphthoflavone. This product is intended for research and analytical applications. Alpha-Naphthoflavone is an orally active flavonoid that is a potent, competitive inhibitor of aromatase with the IC50 and Ki values are 0.5 and 0.2 μM. Alpha-Naphthoflavone can inhibit cell proliferation and induce apoptosis. | ||||||||||||||||||||
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References
- [1]. Campbell DR, et al. Flavonoid inhibition of aromatase enzyme activity in human preadipocytes. J Steroid Biochem Mol Biol. 1993 Sep;46(3):381-8. [Content Brief]
- [2]. Cheng YW, et al. Alpha-naphthoflavone induces vasorelaxation through the induction of extracellular calcium influx and NO formation in endothelium. Naunyn Schmiedebergs Arch Pharmacol. 2003 Nov;368(5):377-85. [Content Brief]
- [3]. Flores-Pérez A, et al. Apoptosis induction and inhibition of HeLa cell proliferation by alpha-naphthoflavone and resveratrol are aryl hydrocarbon receptor-independent. Chem Biol Interact. 2018 Feb 1;281:98-105. [Content Brief]
- [4]. Xia H, et al. Alpha-naphthoflavone attenuates non-alcoholic fatty liver disease in oleic acid-treated HepG2 hepatocytes and in high fat diet-fed mice. Biomed Pharmacother. 2019 Oct;118:109287. [Content Brief]
