61-16-5
61-16-5
Chemical Structure
Methoxamine hydrochloride
- CAS No.: 61-16-5
- Formula:C11H18ClNO3
- Molecular Weight:247.72
IUPAC Name: 2-amino-1-(2,5-dimethoxyphenyl)propan-1-ol hydrochloride
InChIKey: YGRFXPCHZBRUKP-UHFFFAOYSA-N
SMILES: OC(C(N)C)C1=CC(OC)=CC=C1OC.[H]Cl
Biological Activity: Methoxamine hydrochloride is a selective alpha1-adrenergic receptor agonist. Methoxamine hydrochloride causes vasoconstriction and increased peripheral vascular resistance[1][2]. Methoxamine hydrochloride significantly increased the overflow of ATP, ADP and AMP, but not adenosine, by a prazosin-sensitive mechanism in the rabbit pulmonary artery[3].
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Methoxamine hydrochloride | 99.32% | Methoxamine hydrochloride is a selective alpha1-adrenergic receptor agonist. Methoxamine hydrochloride causes vasoconstriction and increased peripheral vascular resistance. Methoxamine hydrochloride significantly increased the overflow of ATP, ADP and AMP, but not adenosine, by a prazosin-sensitive mechanism in the rabbit pulmonary artery. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.81
HY-118470Butaxamine hydrochloride -
Similarity Score 0.80
HY-119868Butaxamine -
Similarity Score 0.73
HY-12749AMidodrine hydrochloride -
Similarity Score 0.73
HY-12749B(R)-Midodrine hydrochloride -
Similarity Score 0.73
HY-12749Midodrine -
Similarity Score 0.68
HY-N15717(erythro) 1′,2′-Dihydroxyasarone -
Similarity Score 0.68
HY-N15717A(threo) 1',2'-Dihydroxyasarone -
Similarity Score 0.67
HY-1707322,3,6-Trimethoxyamphetamine hydrochloride -
Similarity Score 0.67
HY-170743β-Hydroxy 2C-B hydrochloride -
Explore the MedChemAI to find more analogs
References
- [1]. Sanders AB. The roles of methoxamine and norepinephrine in electromechanical dissociation. Ann Emerg Med. 1984;13(9 Pt 2):835-839. [Content Brief]
- [2]. Chang KC. Hypertensive effects of methoxamine on arterial mechanics in rats: analysis based on exponentially tapered T-tube model. Eur J Pharmacol. 1998;350(2-3):195-202. [Content Brief]
- [3]. Takeuchi K, et al. Methoxamine-induced release of endogenous ATP from rabbit pulmonary artery. Eur J Pharmacol. 1994;254(3):287-290. [Content Brief]
