6159-55-3
6159-55-3
Chemical Structure
Vasicine
Synonym(s): Peganine
- CAS No.: 6159-55-3
- Formula:C11H12N2O
- Molecular Weight:188.23
IUPAC Name: (S)-1,2,3,9-tetrahydropyrrolo[2,1-b]quinazolin-3-ol
InChIKey: YIICVSCAKJMMDJ-JTQLQIEISA-N
SMILES: O[C@H]1CCN2C1=NC3=C(C=CC=C3)C2
Biological Activity: Vasicine (peganine) is a quinazoline alkaloid isolated from Justicia adhatoda. Vasicine activates PI3K/Akt signaling pathway, exhibits antioxidant, anti-inflammatory and antibacterial activities[1][2][3].
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Vasicine | 98.80% | Vasicine (peganine) is a quinazoline alkaloid isolated from Justicia adhatoda. Vasicine activates PI3K/Akt signaling pathway, exhibits antioxidant, anti-inflammatory and antibacterial activities. | ||||||||||||||||||||
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References
- [1]. Grange JM, et al. Activity of bromhexine and ambroxol, semi-synthetic derivatives of vasicine from the Indian shrub Adhatoda vasica, against Mycobacterium tuberculosis in vitro. J Ethnopharmacol. 1996 Jan;50(1):49-53. [Content Brief]
- [2]. Jiang T, et al., Protective Effect Of Vasicine Against Myocardial Infarction In Rats Via Modulation Of Oxidative Stress, Inflammation, And The PI3K/Akt Pathway. Drug Des Devel Ther. 2019 Oct 31;13:3773-3784. [Content Brief]
- [3]. Singh VK, et al., Anti-secretory and cyto-protective effects of peganine hydrochloride isolated from the seeds of Peganum harmala on gastric ulcers. Phytomedicine. 2013 Oct 15;20(13):1180-5. [Content Brief]
Keywords
