634907-30-5
Chemical Structure
Censavudine
Synonym(s): Festinavir; BMS-986001; OBP-601
- CAS. Nr.: 634907-30-5
- Formula:C12H12N2O4
- Molecular Weight:248.24
IUPAC Name: 1-((2R,5R)-5-ethynyl-5-(hydroxymethyl)-2,5-dihydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
InChIKey: OSYWBJSVKUFFSU-SKDRFNHKSA-N
SMILES: C#C[C@@]1(O[C@](N(C=C2C)C(NC2=O)=O)([H])C=C1)CO
Biological Activity: Censavudine (OBP-601; BMS-986001), a nucleoside analog, is a nucleoside reverse transcriptase inhibitor. Censavudine is a potent HIV inhibitor with EC50 ranges from 30 nM to 81 nM and 450 nM to 890 nM for HIV-2 and HIV-1, respectively[1][2]. Censavudine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
| Art. -Nr. | Produktname | Reinheit | Beschreibung | Pricing | |||||||||||||||||||
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Censavudine | 98.00% | Censavudine (OBP-601; BMS-986001), a nucleoside analog, is a nucleoside reverse transcriptase inhibitor. Censavudine is a potent HIV inhibitor with EC50 ranges from 30 nM to 81 nM and 450 nM to 890 nM for HIV-2 and HIV-1, respectively. Censavudine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | ||||||||||||||||||||
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Similarity Score 0.76
HY-B0116Stavudine -
Similarity Score 0.74
HY-B0116AStavudine sodium -
Similarity Score 0.67
HY-1542754’-Methylthymidine -
Similarity Score 0.66
HY-W0123113′-Deoxythymidine -
Similarity Score 0.66
HY-1545572′,3′-Didehydro-2′,3′-dideoxy-5-fluorouridine -
Similarity Score 0.65
HY-107082Dioxolane T -
Similarity Score 0.64
HY-1545241-(2-Deoxy-β-D-threo-pentofuranosyl)thymine -
Similarity Score 0.64
HY-N1150S3Thymidine-13C-1 -
Similarity Score 0.64
HY-N1150S5Thymidine-2′-13C -
Explore the MedChemAI to find more analogs
References
- [1]. Robert A Smith, et al. The Nucleoside Analog BMS-986001 Shows Greater In Vitro Activity Against HIV-2 Than Against HIV-1. Antimicrob Agents Chemother. 2015 Dec;59(12):7437-46. [Content Brief]
- [2]. Long Yuan, et al. Dried Blood Spot Analysis Without Dilution: Application to the LC-MS/MS Determination of BMS-986001 in Rat Dried Blood Spot. J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Oct 1;1002:201-9. [Content Brief]
