65664-81-5
65664-81-5
Chemical Structure
Bis-ANS dipotassium
- CAS No.: 65664-81-5
- Formula:C32H22K2N2O6S2
- Molecular Weight:672.85
IUPAC Name: potassium 4,4'-bis(phenylamino)-[1,1'-binaphthalene]-5,5'-disulfonate
InChIKey: VWLWTJHKQHRTNC-UHFFFAOYSA-L
SMILES: O=S(C1=CC=CC2=C(C3=C4C=CC=C(S(=O)(O[K])=O)C4=C(NC5=CC=CC=C5)C=C3)C=CC(NC6=CC=CC=C6)=C12)(O[K])=O
Biological Activity: Bis-ANS dipotassium is a fluorescent probe of hydrophobic protein. Bis-ANS binds to tubulin with a Kd of 2 μM[1]. Bis-ANS dipotassium is a potent biphasic modulator of protein liquid-liquid phase separation (LLPS). Bis-ANS dipotassium promotes LLPS at low concentrations but suppresses LLPS at high concentrations[2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Bis-ANS dipotassium | 98.20% | Bis-ANS dipotassium is a fluorescent probe of hydrophobic protein. Bis-ANS binds to tubulin with a Kd of 2 μM. Bis-ANS dipotassium is a potent biphasic modulator of protein liquid-liquid phase separation (LLPS). Bis-ANS dipotassium promotes LLPS at low concentrations but suppresses LLPS at high concentrations. | ||||||||||||||||||||
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References
- [1]. P Horowitz, et al. Bis(1,8-anilinonaphthalenesulfonate). A novel and potent inhibitor of microtubule assembly. J Biol Chem. 1984 Dec 10;259(23):14647-50. [Content Brief]
- [2]. W. Michael Babinchak, et al. Small molecules as potent biphasic modulators of protein liquid-liquid phase separation. Nature Communications volume 11, Article number: 5574 (2020)
