1. Cell Cycle/DNA Damage
    Cytoskeleton
  2. Microtubule/Tubulin
  3. Bis-ANS dipotassium

Bis-ANS dipotassium 

Cat. No.: HY-129811
Handling Instructions

Bis-ANS dipotassium is a fluorescent probe of hydrophobic protein. Bis-ANS binds to tubulin with a Kd of 2 μM. Bis-ANS dipotassium is a potent biphasic modulator of protein liquid-liquid phase separation (LLPS). Bis-ANS dipotassium promotes LLPS at low concentrations but suppresses LLPS at high concentrations.

For research use only. We do not sell to patients.

Bis-ANS dipotassium Chemical Structure

Bis-ANS dipotassium Chemical Structure

CAS No. : 65664-81-5

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Description

Bis-ANS dipotassium is a fluorescent probe of hydrophobic protein. Bis-ANS binds to tubulin with a Kd of 2 μM[1]. Bis-ANS dipotassium is a potent biphasic modulator of protein liquid-liquid phase separation (LLPS). Bis-ANS dipotassium promotes LLPS at low concentrations but suppresses LLPS at high concentrations[2].

In Vitro

Bis-ANS is a fluorescent molecule that has been used to probe exposed hydrophobic patches in proteins and to monitor the formation of protein aggregates. Bis-ANS is a bivalent naphthalene sulfonate with aniline moieties. Bis-ANS modulates the liquid-liquid phase separation of TDP-43 low complexity domain (LCD)[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

672.85

Formula

C₃₂H₂₂K₂N₂O₆S₂

CAS No.

65664-81-5

SMILES

O=S(C1=CC=CC2=C(C3=C4C=CC=C(S(=O)(O[K])=O)C4=C(NC5=CC=CC=C5)C=C3)C=CC(NC6=CC=CC=C6)=C12)(O[K])=O

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Bis-ANS dipotassiumMicrotubule/TubulinfluorescentprobetubulinliquidphaseseparationLLPSInhibitorinhibitorinhibit

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Bis-ANS dipotassium
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HY-129811
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