65673-63-4
65673-63-4
Chemical Structure
HA14-1
- CAS No.: 65673-63-4
- Formula:C17H17BrN2O5
- Molecular Weight:409.23
IUPAC Name: ethyl (R)-2-amino-6-bromo-4-((R)-1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate
InChIKey: SXJDCULZDFWMJC-AAEUAGOBSA-N
SMILES: CCOC(C1=C(N)OC2=CC=C(Br)C=C2[C@@]1([H])[C@H](C#N)C(OCC)=O)=O
Biological Activity: HA14-1 is a Bcl-2/Bcl-XL antagonist. HA14-1 binds the designated pocket on Bcl-2 with the IC50 of ≈9 μM in competing with the Bcl-2 binding of Flu-BakBH3, and inhibits its function.
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HA14-1 | 98.0% | HA14-1 is a Bcl-2/Bcl-XL antagonist. HA14-1 binds the designated pocket on Bcl-2 with the IC50 of ≈9 μM in competing with the Bcl-2 binding of Flu-BakBH3, and inhibits its function. | ||||||||||||||||||||
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