Nemadipine B
Based on 1 Customer Validation
Nemadipine B is a calcium channel blocker and an EGL-19 antagonist. Nemadipine B induces Egl, Vab and Gro phenotypes in Caenorhabditis elegans.
For research use only. We do not sell to patients.
- Purity: 95.90%
- CAS No.: 79925-38-5
- Formula: C19H21Cl2NO4
- Molecular Weight:398.28
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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High-Throughput Bioactive Compound Library
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All Calcium Channel Isoforms
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Biological Activity
Chemical Information
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CAS No. 79925-38-5
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Appearance Solid
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Molecular Weight 398.28
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Formula C19H21Cl2NO4
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Color White to off-white
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SMILES
O=C(C1=C(C)NC(C)=C(C1C2=C(Cl)C(Cl)=CC=C2)C(OCC)=O)OCC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (251.08 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (6.28 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (278 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.5108 mL | 12.5540 mL | 25.1080 mL | 62.7699 mL |
| 5 mM | 0.5022 mL | 2.5108 mL | 5.0216 mL | 12.5540 mL | |
| 10 mM | 0.2511 mL | 1.2554 mL | 2.5108 mL | 6.2770 mL | |
| 15 mM | 0.1674 mL | 0.8369 mL | 1.6739 mL | 4.1847 mL | |
| 20 mM | 0.1255 mL | 0.6277 mL | 1.2554 mL | 3.1385 mL | |
| 25 mM | 0.1004 mL | 0.5022 mL | 1.0043 mL | 2.5108 mL | |
| 30 mM | 0.0837 mL | 0.4185 mL | 0.8369 mL | 2.0923 mL | |
| 40 mM | 0.0628 mL | 0.3138 mL | 0.6277 mL | 1.5692 mL | |
| 50 mM | 0.0502 mL | 0.2511 mL | 0.5022 mL | 1.2554 mL | |
| 60 mM | 0.0418 mL | 0.2092 mL | 0.4185 mL | 1.0462 mL | |
| 80 mM | 0.0314 mL | 0.1569 mL | 0.3138 mL | 0.7846 mL | |
| 100 mM | 0.0251 mL | 0.1255 mL | 0.2511 mL | 0.6277 mL |
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