6730-83-2
6730-83-2
Chemical Structure
Kaurenoic acid
- CAS. Nr.: 6730-83-2
- Formula:C20H30O2
- Molecular Weight:302.45
IUPAC Name: (4R,4aS,6aS,9R,11aR,11bS)-4,11b-dimethyl-8-methylenetetradecahydro-6a,9-methanocyclohepta[a]naphthalene-4-carboxylic acid
InChIKey: NIKHGUQULKYIGE-OTCXFQBHSA-N
SMILES: C[C@@]1(C(O)=O)CCC[C@@]2(C)[C@@]3([H])[C@@]4(CC([C@H](CC3)C4)=C)CC[C@]12[H]
Biological Activity: Kaurenoic acid is a diterpene derived from Sphagneticola trilobata. Kaurenoic acid has antibacterial, anti-inflammatory, anticonvulsant, analgesic, and aortic vasodilating effects[1][2][3][4].
| Art. -Nr. | Produktname | Reinheit | Beschreibung | Pricing | |||||||||||||||||||
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Kaurenoic acid | 99.93% | Kaurenoic acid is a diterpene derived from Sphagneticola trilobata. Kaurenoic acid has antibacterial, anti-inflammatory, anticonvulsant, analgesic, and aortic vasodilating effects. | ||||||||||||||||||||
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Kaurenoic acid (Standard) | ≥98% | Kaurenoic acid (Standard) is the analytical standard of Kaurenoic acid. This product is intended for research and analytical applications. Kaurenoic acid is a diterpene from Sphagneticola trilobata, inhibits Inflammatory Pain by the inhibition of cytokine production and activation of the NO–cyclic GMP–PKG–ATP-sensitive potassium channel signaling pathway. | ||||||||||||||||||||
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Siegeskaurolic acid | Siegeskaurolic acid is an orally active anti-inflammatory agent. Siegeskaurolic acid inhibits the productions of nitric oxide (NO), prostaglandin E(2) (PGE(2)), tumor necrosis factor-alpha (TNF-alpha) and the activationon of nuclear factor-kappaB . | |||||||||||||||||||||
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Isosteviol (Standard) | ≥98% | Isosteviol (Standard) is the analytical standard of Isosteviol. This product is intended for research and analytical applications. Isosteviol ((-)-Isosteviol) is a derivative of Stevioside through acid catalyzed hydrolysis of Stevioside. Isosteviol inhibits DNA polymerase and DNA topoisomerase and has antibacterial, anticancer and anti-tuberculosis effects. | ||||||||||||||||||||
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Sventenic acid | Sventenic acid is a Diterpenoids product that can be isolated from the herbs of Rabdosia excisa. | |||||||||||||||||||||
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Steviol (Standard) | ≥98% | Steviol (Standard) is the analytical standard of Steviol (HY-N2057). This product is intended for research and analytical applications. Steviol is the main metabolite of steviol glycosides and an inhibitor of AQP2/CFTR. Steviol slows down the growth of renal cysts by inhibiting the activity of CFTR, reducing the expression of AQP2, and promoting the degradation of AQP2 and CFTR. Steviol can be used in the research of polycystic kidney disease. | ||||||||||||||||||||
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Deacetylxylopic acid | Deacetylxylopic acid (ent-15α-Hydroxykaurenoic acid) is a Diterpene product that can be isolated from Blumea eriantha. | |||||||||||||||||||||
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ent-17-Hydroxykaur-15-en-19-oic acid | ent-17-Hydroxykaur-15-en-19-oic acid is a ent-kaurene diterpene that can be isolated from the leaves of Laetia thamnia L.. ent-17-Hydroxykaur-15-en-19-oic acid was cytotoxic to human prostate LNCaP2 cells with IC50 17.63 mg/mL. | |||||||||||||||||||||
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ent-3β-Hydroxykaur-16-en-19-oic acid | ent-3β-Hydroxykaur-16-en-19-oic acid is a Diterpenoids product that can be isolated from the herbs of Wedelia trilobata. | |||||||||||||||||||||
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Grandifloric acid | Grandifloric acid is a Diterpenoids product that can be isolated from the herbs of Siegesbeckia orientalis L.. | |||||||||||||||||||||
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Siegesmethyletheric acid | Siegesmethyletheric acid is isolated from the ethyl acetate fraction of Siegesbeckia orientalis L. (Asteraceae). | |||||||||||||||||||||
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ent-Kauran-17,19-dioic acid | ent-Kauran-17,19-dioic acid (16α-Hydro-ent-kauran-17,19-dioic acid) is an ent-kaurane diterpenoid. | |||||||||||||||||||||
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References
- [1]. Carlos R Tirapelli, et al. Analysis of the mechanisms underlying the vasorelaxant action of kaurenoic acid in the isolated rat aorta. Eur J Pharmacol. 2004 May 25;492(2-3):233-41. [Content Brief]
- [2]. Sergio M Borghi, et al. The diterpene from Sphagneticola trilobata (L.) Pruski, kaurenoic acid, reduces lipopolysaccharide-induced peritonitis and pain in mice. J Ethnopharmacol. 2021 Jun 12:273:113980. [Content Brief]
- [3]. Theophine C Okoye, et al. Anticonvulsant effect of kaurenoic acid isolated from the root bark of Annona senegalensis. Pharmacol Biochem Behav. 2013 Aug:109:38-43. [Content Brief]
- [4]. Mizokami SS, et al. Kaurenoic acid from Sphagneticola trilobata Inhibits Inflammatory Pain: effect on cytokine production and activation of the NO-cyclic GMP-protein kinase G-ATP-sensitive potassium channel signaling pathway. J Nat Prod. 2012 May 25;75(5):896-904. [Content Brief]
