69427-46-9
69427-46-9
Chemical Structure
13-cis Acitretin
Synonym(s): Isoacitretin; Ro 13-7652
- CAS No.: 69427-46-9
- Formula:C21H26O3
- Molecular Weight:326.43
IUPAC Name: (2Z,4E,6E,8E)-9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethylnona-2,4,6,8-tetraenoic acid
InChIKey: IHUNBGSDBOWDMA-UGOGCBOOSA-N
SMILES: O=C(/C=C(\C=C\C=C(\C=C\C1=C(C=C(C(C)=C1C)OC)C)C)C)O
Biological Activity: 13-cis Acitretin (Isoacitretin; Ro 13-7652) is a retinoid and the major in vivo metabolite of etretinate. 13-cis Acitretin is formed via in vivo isomerization of etretinate. 13-cis Acitretin serves as the primary metabolite in blood[1][2].
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13-cis Acitretin | 13-cis Acitretin (Isoacitretin; Ro 13-7652) is a retinoid and the major in vivo metabolite of etretinate. 13-cis Acitretin is formed via in vivo isomerization of etretinate. 13-cis Acitretin serves as the primary metabolite in blood. | |||||||||||||||||||||
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References
- [1]. Stuck AE, et al. Pharmacokinetics of acitretin and its 13-cis metabolite in patients on haemodialysis. Br J Clin Pharmacol. 1989;27(3):301-304. [Content Brief]
- [2]. Kumar A, et al. Stability-indicating validation of acitretin and isoacitretin in human plasma by LC-ESI-MS/MS bioanalytical method and its application to pharmacokinetic analysis. Biomed Chromatogr. 2011;25(6):680-688. [Content Brief]
