Pharmacokinetics of acitretin and its 13-cis metabolite in patients on haemodialysis

  • Br J Clin Pharmacol. 1989 Mar;27(3):301-4. doi: 10.1111/j.1365-2125.1989.tb05369.x.
A E Stuck  1 ,  C J Brindley ,  A Busslinger ,  F J Frey
Affiliations
  • 1. Medizinische Universitätspoliklinik, Bern, Switzerland.
PMID: 2524207 DOI: 10.1111/j.1365-2125.1989.tb05369.x
Abstract

1. Plasma concentrations of acitretin and its metabolite (13-cis acitretin) were measured in six patients on haemodialysis and six subjects without renal failure following a single oral dose of 50 mg of acitretin. 2. The mean areas under the plasma concentration vs time curves of acitretin and its metabolite were about 50% lower in patients on haemodialysis. 3. No retinoids were detectable in the dialysate.

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