69655-05-6
69655-05-6
Chemical Structure
Didanosine
Synonym(s): 2',3'-Dideoxyinosine; ddI
- CAS No.: 69655-05-6
- Formula:C10H12N4O3
- Molecular Weight:236.23
IUPAC Name: 9-((2R,5S)-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol
InChIKey: BXZVVICBKDXVGW-NKWVEPMBSA-N
SMILES: OC[C@@H]1CC[C@H](N2C3=C(N=C2)C(O)=NC=N3)O1
Biological Activity: Didanosine (2',3'-Dideoxyinosine; ddI) is a a potent and orally active dideoxynucleoside analogue, and also is a potent nucleoside reverse transcriptase inhibitor. Didanosine shows antiretroviral activity for HIV[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Didanosine | 99.45% | Didanosine (2',3'-Dideoxyinosine; ddI) is a a potent and orally active dideoxynucleoside analogue, and also is a potent nucleoside reverse transcriptase inhibitor. Didanosine shows antiretroviral activity for HIV. | ||||||||||||||||||||
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Didanosine (Standard) | ≥98% | Didanosine (Standard) is the analytical standard of Didanosine. This product is intended for research and analytical applications. Didanosine (2',3'-Dideoxyinosine; ddI) is a a potent and orally active dideoxynucleoside analogue, and also is a potent nucleoside reverse transcriptase inhibitor. Didanosine shows antiretroviral activity for HIV. | ||||||||||||||||||||
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Didanosine-d2 | Didanosine-d2 is the deuterium labeled Didanosine. Didanosine (Videx) is a reverse transcriptase inhibitor with an IC50 of 0.49 μM. | |||||||||||||||||||||
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Didanosine-13C2,15N | Didanosine-13C2,15N (2',3'-Dideoxyinosine-13C2,15N; ddI-13C2,15N) is the 13C- and 15N-labeled labeled Didanosine (HY-B0249). Didanosine (2',3'-Dideoxyinosine; ddI) is a a potent and orally active dideoxynucleoside analogue, and also is a potent nucleoside reverse transcriptase inhibitor. Didanosine shows antiretroviral activity for HIV. | |||||||||||||||||||||
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References
- [1]. Munir N.Nassar, et al. Analytical profiles of drug substances and excipients. Journals & Books, 1993, 185-227.
- [2]. Braga Neto MB, et al. Evaluation of HIV protease and nucleoside reverse transcriptase inhibitors on proliferation, necrosis, apoptosis in intestinal epithelial cells and electrolyte and water transport and epithelial barrier function in mice. BMC Gastroenterol. 2010 Aug 11;10:90. [Content Brief]
- [3]. Caroline M. Perry, et al. Didanosine. Drugs, 1999, 58, 1099-1135.
