6983-79-5
6983-79-5
Chemical Structure
Bixin
- CAS No.: 6983-79-5
- Formula:C25H30O4
- Molecular Weight:394.50
IUPAC Name: (2E,4E,6E,8E,10E,12E,14E,16Z,18E)-20-methoxy-4,8,13,17-tetramethyl-20-oxoicosa-2,4,6,8,10,12,14,16,18-nonaenoic acid
InChIKey: RAFGELQLHMBRHD-SLEZCNMESA-N
SMILES: OC(/C=C/C(C)=C/C=C/C(C)=C/C=C/C=C(C)/C=C/C=C(C)\C=C\C(OC)=O)=O
Biological Activity: Bixin is an orally active carotenoid found in the seeds of Bixa orellana. Bixin induces apoptosis in cancer cells. Bixin possessing anti-inflammatory, anti-tumor and anti-oxidant activities. Bixin treatment ameliorated cardiac dysfunction through inhibiting fibrosis, inflammation and reactive oxygen species (ROS) generation[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Bixin | 98.61% | Bixin is an orally active carotenoid found in the seeds of Bixa orellana. Bixin induces apoptosis in cancer cells. Bixin possessing anti-inflammatory, anti-tumor and anti-oxidant activities. Bixin treatment ameliorated cardiac dysfunction through inhibiting fibrosis, inflammation and reactive oxygen species (ROS) generation. | ||||||||||||||||||||
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Bixin (Standard) | ≥98% | Bixin (Standard) is the analytical standard of Bixin. This product is intended for research and analytical applications.Bixin is an orally active carotenoid found in the seeds of Bixa orellana. Bixin induces apoptosis in cancer cells. Bixin possessing anti-inflammatory, anti-tumor and anti-oxidant activities. Bixin treatment ameliorated cardiac dysfunction through inhibiting fibrosis, inflammation and reactive oxygen species (ROS) generation. | ||||||||||||||||||||
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Apo-12'-lycopenal | Apo-12'-lycopenal is a Lycopene (HY-N0287) metabolite. Apo-12'-lycopenal promotes adipocyte differentiation and adiponectin secretion via PPAR-γ activation. | |||||||||||||||||||||
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Crocetin disodium | 99.30% | Crocetin (Transcrocetin) disodium, extracted from saffron (Crocus sativus L.), acts as an NMDA receptor antagonist with high affinity. | ||||||||||||||||||||
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Crocetin dialdehyde | 99.75% | Crocetin dialdehyde is a non-volatile apocarotenoid obtained by the action of the plastidic enzyme CCD2 over the carotenoid zeaxanthin in saffron. Crocetin dialdehyde can be converted into Crocetin (HY-N2072) by aldehyde dehydrogenases (ALDHs). Crocetin dialdehyde has no effect on the liver in mice. | ||||||||||||||||||||
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Methyl-bixin | Methyl-bixin (compound 2) is a diapocarotenoid that can found in the seed coat of Bixa orellana L. (annatto). | |||||||||||||||||||||
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Crocetin | 98.07% | Crocetin (Transcrocetin) is an aglycone of crocin. Crocetin is an orally active and brain-penetrant. Crocetin shows strong NMDA receptor affinity and channel opening activity. Crocetin can downregulate the proinflammatory cytokines and COX-2 exoression. Crocetin can inhibit apoptosis and activation of MAPK. Crocetin can delay delays brain and body aging. Crocetin can be used for the researches of cancer, neurological disease and inflammation, such as cervical cancer and ischemia. | ||||||||||||||||||||
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Crocetine dimethyl ester | 98.30% | Crocetine dimethyl ester (Dimethylcrocetin) is found in the stigmas of saffron (Crocus sativus L.), and has antioxidant activity. | ||||||||||||||||||||
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Crocetin monomethyl ester | 98.0% | Crocetin monomethyl ester, isolated from Crocus sativus, possesses anti-inflammatory, neuroprotective and antioxidant activity. Crocetin monomethyl ester promotes clearance of amyloid-β by inducing autophagy via the STK11/LKB1-mediated AMPK pathway. | ||||||||||||||||||||
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Norbixin | Norbixin is an orally active natural product with multiple activities such as retinal protection and oxidative stress regulation. Norbixin scavenges ROS, chelates metal ions, regulates plasmid and genomic DNA breakage, inhibits H2O2-induced mutagenesis, activates PPAR-α, modulates lipid levels, restores or regulates antioxidant enzyme activity, and alters NO levels. Norbixin prevents A2E accumulation and protects photoreceptor cells and retinal pigment epithelial cells. Norbixin is a derivative of Bixin (HY-N6884). Norbixin can be used in research related to diseases such as macular degeneration and diabetes, and also serves as a natural textile dye. | |||||||||||||||||||||
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4,4'-Diapo-ω,ω-carotene-4,4'-dial | 4,4'-Diapo-ω,ω-carotene-4,4'-dial is a carotenoid pigment. Carotenoids are important biological active, and may regulate cellular differentiation, growth control, photooxidative protection, cell membrane stability, photosynthesis, vision process and nutrition. | |||||||||||||||||||||
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Citranaxanthin | Citranaxanthin is a carotenoid that can be isolated from Sea Hare Dolabella auriculari. Carotenoids are important biological active, and may regulate cellular differentiation, growth control, photooxidative protection, cell membrane stability, photosynthesis, vision process and nutrition. | |||||||||||||||||||||
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References
- [1]. Xu Z, et al. Bixin ameliorates high fat diet-induced cardiac injury in mice through inflammation and oxidative stress suppression. Biomed Pharmacother. 2017 May;89:991-1004. [Content Brief]
- [2]. Kusmita L, et al. Bixa orellana L. carotenoids: antiproliferative activity on human lung cancer, breast cancer, and cervical cancer cells in vitro. Nat Prod Res. 2022 Dec;36(24):6421-6427. [Content Brief]
