71079-08-8
71079-08-8
Chemical Structure
FOY 251 free base
- CAS No.: 71079-08-8
- Formula:C16H15N3O4
- Molecular Weight:313.31
IUPAC Name: 2-(4-((4-guanidinobenzoyl)oxy)phenyl)acetic acid
InChIKey: XTKGXPFBKPYFDW-UHFFFAOYSA-N
SMILES: O=C(O)CC1=CC=C(OC(C2=CC=C(NC(N)=N)C=C2)=O)C=C1
Biological Activity: FOY 251 free base, an anti-proteolytic active metabolite of Camostate (HY-13512), acts as a proteinase inhibitor[1][2]. FOY 25 free base inhibits SARS-CoV-2 infection in cells assay[3].
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FOY 251 free base | FOY 251 free base, an anti-proteolytic active metabolite of Camostate (HY-13512), acts as a proteinase inhibitor. FOY 25 free base inhibits SARS-CoV-2 infection in cells assay. | |||||||||||||||||||||
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References
- [1]. K Beckh, et al. Elimination of the Low-Molecular Weight Proteinase Inhibitor Camostate (FOY 305) and Its Degradation Products by the Rat Liver. Res Exp Med (Berl). 1987;187(6):401-6. [Content Brief]
- [2]. Ai Maekawa, et al. Camostat Mesilate Inhibits Prostasin Activity and Reduces Blood Pressure and Renal Injury in Salt-Sensitive Hypertension. J Hypertens . 2009 Jan;27(1):181-9. [Content Brief]
- [3]. Markus Hoffmann, et al. Camostat mesylate inhibits SARS-CoV-2 activation by TMPRSS2-related proteases and its metabolite GBPA exerts antiviral activity. bioRxiv. 2020 Aug 5;2020.08.05.237651. [Content Brief]
