71308-35-5
Chemical Structure
Tyrphostin AG17
- CAS No.: 71308-35-5
- Formula:C12H10N2O
- Molecular Weight:198.22
InChIKey: OEDSJMUPYHBZAL-UHFFFAOYSA-N
SMILES: N#C/C(C#N)=C/C1=CC(C)=C(O)C(C)=C1
Biological Activity: Tyrphostin AG17 is an orally active CDK2 inhibitor and EGFR tyrosine kinase antagonist. Tyrphostin AG17 reduces the levels of p21 and p16. Tyrphostin AG17 induces G1 phase cell cycle arrest, Apoptosis, mitochondrial dysfunction, decreased ATP levels, and inhibits DNA, RNA and protein synthesis, adipogenesis, and lipid synthesis. Tyrphostin AG17 inhibits fat accumulation, white adipose tissue hypertrophy, and alterations of glycogen and lipid inclusions in hepatocytes in obese mice without changing their serum biochemical parameters. Tyrphostin AG17 exhibits anticancer effects. Tyrphostin AG17 can be used in research related to immunoblastic lymphoma, leukemia, ovarian cancer, glioblastoma, colon cancer, breast cancer, melanoma, obesity and hepatic steatosis[1][2][3].
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Tyrphostin AG17 | Tyrphostin AG17 is an orally active CDK2 inhibitor and EGFR tyrosine kinase antagonist. Tyrphostin AG17 reduces the levels of p21 and p16. Tyrphostin AG17 induces G1 phase cell cycle arrest, Apoptosis, mitochondrial dysfunction, decreased ATP levels, and inhibits DNA, RNA and protein synthesis, adipogenesis, and lipid synthesis. Tyrphostin AG17 inhibits fat accumulation, white adipose tissue hypertrophy, and alterations of glycogen and lipid inclusions in hepatocytes in obese mice without changing their serum biochemical parameters. Tyrphostin AG17 exhibits anticancer effects. Tyrphostin AG17 can be used in research related to immunoblastic lymphoma, leukemia, ovarian cancer, glioblastoma, colon cancer, breast cancer, melanoma, obesity and hepatic steatosis. | |||||||||||||||||||||
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- [1]. Palumbo GA, et al. The tryphostin AG17 induces apoptosis and inhibition of cdk2 activity in a lymphoma cell line that overexpresses bcl-2. Cancer research. 1997 Jun 15;57(12):2434-9. [Content Brief]
- [2]. Burger AM, et al. Tyrphostin AG17, [(3,5-Di-tert-butyl-4-hydroxybenzylidene)- malononitrile], inhibits cell growth by disrupting mitochondria. Cancer research. 1995 Jul 01;55(13):2794-9. [Content Brief]
- [3]. Camacho A, et al. Tyrphostin AG17 inhibits adipocyte differentiation in vivo and in vitro. Lipids in health and disease. 2018 May 29;17(1):128. [Content Brief]
Keywords
