7174-27-8
7174-27-8
Chemical Structure
Vasicine hydrochloride
Synonym(s): Peganine hydrochloride
- CAS No.: 7174-27-8
- Formula:C11H13ClN2O
- Molecular Weight:224.69
IUPAC Name: (S)-1,2,3,9-tetrahydropyrrolo[2,1-b]quinazolin-3-ol hydrochloride
InChIKey: CSDQSAHJCAKJPT-PPHPATTJSA-N
SMILES: O[C@H]1CCN2C1=NC3=C(C=CC=C3)C2.[H]Cl
Biological Activity: Vasicine hydrochloride (peganine hydrochloride) is a quinazoline alkaloid isolated from Justicia adhatoda. Vasicine hydrochloride activates PI3K/Akt signaling pathway, exhibits antioxidant, anti-inflammatory and antibacterial activities[1][2][3].
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Vasicine hydrochloride | 98.62% | Vasicine hydrochloride (peganine hydrochloride) is a quinazoline alkaloid isolated from Justicia adhatoda. Vasicine hydrochloride activates PI3K/Akt signaling pathway, exhibits antioxidant, anti-inflammatory and antibacterial activities. | ||||||||||||||||||||
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Vasicine hydrochloride (Standard) | ≥98% | Vasicine (hydrochloride) (Standard) is the analytical standard of Vasicine (hydrochloride). This product is intended for research and analytical applications. Vasicine hydrochloride (peganine hydrochloride) is a quinazoline alkaloid isolated from Justicia adhatoda. Vasicine hydrochloride activates PI3K/Akt signaling pathway, exhibits antioxidant, anti-inflammatory and antibacterial activities. | ||||||||||||||||||||
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References
- [1]. Grange JM, et al. Activity of bromhexine and ambroxol, semi-synthetic derivatives of vasicine from the Indian shrub Adhatoda vasica, against Mycobacterium tuberculosis in vitro. J Ethnopharmacol. 1996 Jan;50(1):49-53. [Content Brief]
- [2]. Jiang T, et al., Protective Effect Of Vasicine Against Myocardial Infarction In Rats Via Modulation Of Oxidative Stress, Inflammation, And The PI3K/Akt Pathway. Drug Des Devel Ther. 2019 Oct 31;13:3773-3784. [Content Brief]
- [3]. Singh VK, et al., Anti-secretory and cyto-protective effects of peganine hydrochloride isolated from the seeds of Peganum harmala on gastric ulcers. Phytomedicine. 2013 Oct 15;20(13):1180-5. [Content Brief]
