74129-03-6
Chemical Structure
Tebuquine
Synonym(s): WR228258
- CAS No.: 74129-03-6
- Formula:C26H25Cl2N3O
- Molecular Weight:466.40
IUPAC Name: 3-((tert-butylamino)methyl)-4'-chloro-5-((7-chloroquinolin-4-yl)amino)-[1,1'-biphenyl]-2-ol
InChIKey: BCHMRNALCJISMZ-UHFFFAOYSA-N
SMILES: ClC1=CC=C(C2=CC(NC3=C4C=CC(Cl)=CC4=NC=C3)=CC(CNC(C)(C)C)=C2O)C=C1
Biological Activity: Tebuquine (WR228258), a 4-aminoquinoline, is a potent antimalarial agent. Tebuquine is active against the Chloroquine (HY-17589A) sensitive HB3 strain and the Chloroquine resistant K1 strain of Plasmodium falciparum with IC50s of 0.9 nM and 20.8 nM, respectively[1].
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Tebuquine | Tebuquine (WR228258), a 4-aminoquinoline, is a potent antimalarial agent. Tebuquine is active against the Chloroquine (HY-17589A) sensitive HB3 strain and the Chloroquine resistant K1 strain of Plasmodium falciparum with IC50s of 0.9 nM and 20.8 nM, respectively. | |||||||||||||||||||||
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Keywords
