7432-23-7
Chemical Structure
γ-Glu-Tyr
- CAS No.: 7432-23-7
- Formula:C14H18N2O6
- Molecular Weight:310.30
InChIKey: VVLXCWVSSLFQDS-QWRGUYRKSA-N
SMILES: OC([C@@H](N)CCC(N[C@H](C(O)=O)CC1=CC=C(C=C1)O)=O)=O
Biological Activity: γ-Glu-Tyr is an orally active gut microbiota-derived metabolite and a competitive DPP-IV inhibitor with an IC50 of 6.77 mM against hDPP-IV. γ-Glu-Tyr weakly activates hCaSR. γ-Glu-Tyr decreases colonic pro-inflammatory cytokine (IL-6, IL-1β, TNF-α) levels. γ-Glu-Tyr activates the cAMP/PKA signaling pathway and inhibits NF-κB phosphorylation, thereby reducing inflammatory responses. γ-Glu-Tyr can be used for research on type 2 diabetes and ulcerative colitis[1][2][3].
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γ-Glu-Tyr | 99.37% | γ-Glu-Tyr is an orally active gut microbiota-derived metabolite and a competitive DPP-IV inhibitor with an IC50 of 6.77 mM against hDPP-IV. γ-Glu-Tyr weakly activates hCaSR. γ-Glu-Tyr decreases colonic pro-inflammatory cytokine (IL-6, IL-1β, TNF-α) levels. γ-Glu-Tyr activates the cAMP/PKA signaling pathway and inhibits NF-κB phosphorylation, thereby reducing inflammatory responses. γ-Glu-Tyr can be used for research on type 2 diabetes and ulcerative colitis. | ||||||||||||||||||||
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References
- [1]. Yang J, et al. γ‐Glu‐Met synthesised using a bacterial glutaminase as a potential inhibitor of dipeptidyl peptidase IV[J]. International Journal of Food Science & Technology, 2018, 53(5): 1166-1175.
- [2]. Yamamoto M, et al. N-terminal [Glu] moiety of γ-glutamyl peptides contributes largely to the activation of human calcium-sensing receptor, a receptor. Bioscience, biotechnology, and biochemistry. 2020 Jul;84(7):1497-1500.
- [3]. Zheng X, et al. Asiatic Acid Alleviates Ulcerative Colitis Through a Gut Microbiota-Driven cAMP/PKA/NF-κB Pathway: γ-Glutamyltyrosine Is a Crucial Player. Phytotherapy research : PTR. 2026 Jan;40(1):267-285. [Content Brief]
