765-87-7
765-87-7
Chemical Structure
1,2-Cyclohexanedione
- CAS No.: 765-87-7
- Formula:C6H8O2
- Molecular Weight:112.13
IUPAC Name: cyclohexane-1,2-dione
InChIKey: OILAIQUEIWYQPH-UHFFFAOYSA-N
SMILES: O=C1C(CCCC1)=O
Biological Activity: 1,2-Cyclohexanedione is an arginine modification reagent. 1,2-Cyclohexanedione interferes with the degradation of low-density lipoprotein by modifying the arginine group in apolipoprotein. 1,2-Cyclohexanedione can be used in the research of familial hypercholesterolemia[1][2][3].
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1,2-Cyclohexanedione | 1,2-Cyclohexanedione is an arginine modification reagent. 1,2-Cyclohexanedione interferes with the degradation of low-density lipoprotein by modifying the arginine group in apolipoprotein. 1,2-Cyclohexanedione can be used in the research of familial hypercholesterolemia. | |||||||||||||||||||||
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1,2-Cyclohexanedione (Standard) | ≥98% | 1,2-Cyclohexanedione is an endogenous metabolite. | ||||||||||||||||||||
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References
- [1]. Baker GF, et al. Glucose transport inhibitors protect against 1,2-cyclohexanedione-produced potassium loss from human red blood cells. Exp Physiol. 1998 Mar;83(2):239-42. [Content Brief]
- [2]. Knight BL, et al. Degradation by cultured fibroblasts and macrophages of unmodified and 1,2-cyclohexanedione-modified low-density lipoprotein from normal and homozygous familial hypercholesterolaemic subjects. Biochem J. 1982 Jan 15;202(1):145-52. [Content Brief]
- [3]. Lanza L, et al. Identification and Characterization of Thiamine Diphosphate-Dependent Lyases with an Unusual CDG Motif. Angew Chem Int Ed Engl. 2024 Aug 19;63(34):e202404045. [Content Brief]
