76958-67-3
76958-67-3
Chemical Structure
Hypothemycin
- CAS No.: 76958-67-3
- Formula:C19H22O8
- Molecular Weight:378.37
IUPAC Name: (1aR,3S,4S,9S,15bR,Z)-3,4,12-trihydroxy-14-methoxy-9-methyl-1a,3,4,8,9,15b-hexahydro-5H-benzo[c]oxireno[2,3-e][1]oxacyclotetradecine-5,11(2H)-dione
InChIKey: SSNQAUBBJYCSMY-KNTMUCJRSA-N
SMILES: COC1=CC(O)=C(C(O[C@@H](C)C/C=C\C2=O)=O)C([C@@H](O3)[C@@]3([H])C[C@H](O)[C@@H]2O)=C1
Biological Activity: Hypothemycin, a fungal polyketide, is a multikinase inhibitor with Kis of 10/70 nM, 17/38 nM, 90 nM, 900 nM/1.5 μM, and 8.4/2.4 μM for VEGFR2/VEGFR1, MEK1/MEK2, FLT-3, PDGFRβ/PDGFRα, and ERK1/ERK2, respectively[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Hypothemycin | 96.95% | Hypothemycin, a fungal polyketide, is a multikinase inhibitor with Kis of 10/70 nM, 17/38 nM, 90 nM, 900 nM/1.5 μM, and 8.4/2.4 μM for VEGFR2/VEGFR1, MEK1/MEK2, FLT-3, PDGFRβ/PDGFRα, and ERK1/ERK2, respectively. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.81
HY-N14536Dihydrohypothemycin -
Similarity Score 0.74
HY-W714151Ganglioside ga1 -
Similarity Score 0.71
HY-123586L-783277 -
Similarity Score 0.66
HY-126865Z-7-Oxozeaenol -
Similarity Score 0.66
HY-N8551(5E)-7-Oxozeaenol -
Similarity Score 0.59
HY-120349LL-Z1640-4 -
Similarity Score 0.59
HY-N16062Zeaenol -
Similarity Score 0.57
HY-N10219Dihydroaltenuene B -
Similarity Score 0.57
HY-N16055Cochliomycin B -
Explore the MedChemAI to find more analogs
References
- [1]. Schirmer A, et al. Targeted covalent inactivation of protein kinases by resorcylic acid lactone polyketides. Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4234-9. [Content Brief]
- [2]. Nishino M, et al. Hypothemycin, a fungal natural product, identifies therapeutic targets in Trypanosoma brucei. Elife. 2013 Jul 9;2:e00712. [Content Brief]
