77-51-0
Chemical Structure
Isoaminile
- CAS No.: 77-51-0
- Formula:C16H24N2
- Molecular Weight:244.38
IUPAC Name: 4-(dimethylamino)-2-isopropyl-2-phenylpentanenitrile
InChIKey: WFLSCFISQHLEED-UHFFFAOYSA-N
SMILES: N#CC(C(C)C)(CC(N(C)C)C)C1=CC=CC=C1
Biological Activity: Isoaminile is an antitussive agent and an anticholinergic compound with antimuscarinic and antinicotinic properties. Isoaminile blocks the effects of acetylcholine and McN-A-343 at ganglionic sites, inhibits responses to preganglionic sympathetic and splanchnic nerve stimulation, and does not affect postganglionic nerve- or adrenergic-mediated responses. Isoaminile inhibits nictitating membrane contraction and induced hypertension, suppresses isolated guinea pig atrial activity, and stimulates central vagal nerve activity to trigger bradycardia. Isoaminile exerts effects of antitussive action, respiratory inhibition, central nervous system excitation, and cardiovascular function regulation[1][2][3][4].
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Isoaminile | Isoaminile is an antitussive agent and an anticholinergic compound with antimuscarinic and antinicotinic properties. Isoaminile blocks the effects of acetylcholine and McN-A-343 at ganglionic sites, inhibits responses to preganglionic sympathetic and splanchnic nerve stimulation, and does not affect postganglionic nerve- or adrenergic-mediated responses. Isoaminile inhibits nictitating membrane contraction and induced hypertension, suppresses isolated guinea pig atrial activity, and stimulates central vagal nerve activity to trigger bradycardia. Isoaminile exerts effects of antitussive action, respiratory inhibition, central nervous system excitation, and cardiovascular function regulation. | |||||||||||||||||||||
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References
- [1]. Bastos WP, Ramos AO. Isoaminile as inhibitor of muscarinic and nicotinic ganglionic receptors. Pharmacology. 1970 May 28;4(1):39-44.
- [2]. Nascimento DC, Sakate M. Antagonism produced by hypertonic nutrient solutions on the depressive effect of carbofuran on isolated guinea pig atria. Pharmacological research. 1996;33(4-5):251-4.
- [3]. Graham JD. Evaluation of isoaminile citrate as an antitussive. The Journal of New Drugs. 1962 Jan 2;2(1):43-9.
- [4]. Intravenous broad-spectrum I. Inactivated lactobacilli. Vaccine from.
