77408-67-4
Chemical Structure
P18IN011
- CAS No.: 77408-67-4
- Formula:C15H12N2O5S
- Molecular Weight:332.33
IUPAC Name: benzo[d]isoxazol-3-yl 4-acetamidobenzenesulfonate
InChIKey: SIXNKGXJEIVCDH-UHFFFAOYSA-N
SMILES: O=C(NC1=CC=C(C=C1)S(=O)(=O)OC2=NOC=3C=CC=CC23)C
Biological Activity: P18IN011 is an inhibitor that specifically targets the interaction between p18(INK4C) and CDK6, with an IC50 of 3.61 μM against mouse p18INK4C. P18IN011 relieves p18-mediated CDK6 inhibition, thereby effectively regulating the G1 phase cell cycle checkpoint. P18IN011 significantly enhances the proliferation, self-renewal and bone marrow reconstitution abilities of hematopoietic stem cells, and increases the frequency of primitive hematopoietic cells to promote cobblestone area formation. Acting specifically on p18-expressing hematopoietic cells via CDK4/6, P18IN011 not only supports the ex vivo expansion of human umbilical cord blood hematopoietic stem cells, but also maintains their long-term reconstitution capacity during in vitro culture to enable multi-lineage transplantation[1][2][3].
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P18IN011 | P18IN011 is an inhibitor that specifically targets the interaction between p18(INK4C) and CDK6, with an IC50 of 3.61 μM against mouse p18INK4C. P18IN011 relieves p18-mediated CDK6 inhibition, thereby effectively regulating the G1 phase cell cycle checkpoint. P18IN011 significantly enhances the proliferation, self-renewal and bone marrow reconstitution abilities of hematopoietic stem cells, and increases the frequency of primitive hematopoietic cells to promote cobblestone area formation. Acting specifically on p18-expressing hematopoietic cells via CDK4/6, P18IN011 not only supports the ex vivo expansion of human umbilical cord blood hematopoietic stem cells, but also maintains their long-term reconstitution capacity during in vitro culture to enable multi-lineage transplantation. | |||||||||||||||||||||
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References
- [1]. Watt S M, et al. Umbilical cord blood hematopoietic stem and progenitor cell expansion for therapeutic use[M]//Umbilical cord blood banking for clinical application and regenerative medicine. IntechOpen, 2017.
- [2]. Gao Y, et al. Small-molecule inhibitors targeting INK4 protein p18(INK4C) enhance ex vivo expansion of haematopoietic stem cells. Nature communications. 2015 Feb 18;6:6328. [Content Brief]
- [3]. Zhang Y, et al. Novel chemical attempts at ex vivo hematopoietic stem cell expansion. International journal of hematology. 2016 May;103(5):519-29. [Content Brief]
