804-63-7
804-63-7
Chemical Structure
Quinine hemisulfate
- CAS No.: 804-63-7
- Formula:C20H24N2O2.1/2H2SO4
- Molecular Weight:373.45
SMILES: O[C@@H]([C@@]1([H])[N@@](CC2)C[C@H](C=C)[C@@H]2C1)C3=CC=NC4=CC=C(OC)C=C34.O=S(O)(O)=O.[1/2]
Biological Activity: Quinine hemisulfate is an orally active alkaloid extracted from cinchona bark and can be used in anti-malarial studies. Quinine hemisulfate is a potassium channel inhibitor that inhibits WT mouse Slo3 (KCa5.1) channel currents evoked by voltage pulses to +100 mV with an IC50 of 169 μM[1][2].
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Quinine hemisulfate | Quinine hemisulfate is an orally active alkaloid extracted from cinchona bark and can be used in anti-malarial studies. Quinine hemisulfate is a potassium channel inhibitor that inhibits WT mouse Slo3 (KCa5.1) channel currents evoked by voltage pulses to +100 mV with an IC50 of 169 μM. | |||||||||||||||||||||
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References
- [1]. Shilu Malakar，et al. Drug repurposing of quinine as antiviral against dengue virus infection. Virus Res. 2018 Aug 15;255:171-178. doi: 10.1016/j.virusres.2018.07.018. Epub 2018 Jul 25. [Content Brief]
- [2]. Jhanwar, Deepika，et al. Chemoprevention of DMBA induced skin carcinogenesis in swiss albino mice by quinine sulfate.(2016): 2636-2640.
