82508-31-4
Chemical Structure
Pseudolaric Acid B
- CAS No.: 82508-31-4
- Formula:C23H28O8
- Molecular Weight:432.46
IUPAC Name: (2E,4E)-5-((3R,4S,4aS,9aR)-4a-acetoxy-7-(methoxycarbonyl)-3-methyl-1-oxo-3,4,4a,5,6,9-hexahydro-1H-4,9a-ethanocyclohepta[c]pyran-3-yl)-2-methylpenta-2,4-dienoic acid
InChIKey: VDGOFNMYZYBUDT-YDRCMHEVSA-N
SMILES: O=C(C1=CC[C@@]([C@@](CC1)(OC(C)=O)[C@]2([H])[C@@](C)(/C=C/C=C(C(O)=O)\C)O3)(CC2)C3=O)OC
Biological Activity: Pseudolaric Acid B is an orally active diterpene acid. Pseudolaric Acid B has anti-fungal, anti-fertility, anti-angiogenesis and anticancer activity, and can induce tumor cell apoptosis and autophagy. In addition, Pseudolaric Acid B can inhibit the secretion of hepatitis B virus (HBV) and has immunosuppressive effect, selectively inhibiting the proliferation of T lymphocytes and the production of IL-2[1][2][3][4][5].
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Pseudolaric Acid B | 98.67% | Pseudolaric Acid B is an orally active diterpene acid. Pseudolaric Acid B has anti-fungal, anti-fertility, anti-angiogenesis and anticancer activity, and can induce tumor cell apoptosis and autophagy. In addition, Pseudolaric Acid B can inhibit the secretion of hepatitis B virus (HBV) and has immunosuppressive effect, selectively inhibiting the proliferation of T lymphocytes and the production of IL-2. | ||||||||||||||||||||
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Pseudolaric Acid B (Standard) | ≥98% | Pseudolaric Acid B (Standard) is the analytical standard of Pseudolaric Acid B. This product is intended for research and analytical applications. Pseudolaric Acid B is an orally active diterpene acid. Pseudolaric Acid B has anti-fungal, anti-fertility, anti-angiogenesis and anticancer activity, and can induce tumor cell apoptosis and autophagy. In addition, Pseudolaric Acid B can inhibit the secretion of hepatitis B virus (HBV) and has immunosuppressive effect, selectively inhibiting the proliferation of T lymphocytes and the production of IL-2. | ||||||||||||||||||||
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Similarity Score 0.92
HY-N3267Methyl pseudolarate B -
Similarity Score 0.90
HY-N6910Pseudolaric Acid C2 -
Similarity Score 0.85
HY-N0673Pseudolaric Acid A -
Similarity Score 0.83
HY-N0672RPseudolaric Acid C (Standard) -
Similarity Score 0.82
HY-N3268Methyl pseudolarate A -
Similarity Score 0.75
HY-N3697Demethoxydeacetoxypseudolaric acid B -
Similarity Score 0.74
HY-N17986Pseudolaric acid G -
Similarity Score 0.73
HY-N6938Pseudolaric acid B β-D-glucoside -
Similarity Score 0.71
HY-N3696Deacetylpseudolaric acid A -
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References
- [1]. Yu J, et al. Pseudolaric acid B activates autophagy in MCF-7 human breast cancer cells to prevent cell death. Oncol Lett. 2016 Mar;11(3):1731-1737. [Content Brief]
- [2]. Yu J, et al. Pseudolaric acid B inhibits the secretion of hepatitis B virus. Oncol Rep. 2017 Jan;37(1):519-525. [Content Brief]
- [3]. Li MH, et al. Pseudolaric acid B inhibits angiogenesis and reduces hypoxia-inducible factor 1alpha by promoting proteasome-mediated degradation. Clin Cancer Res. 2004 Dec 15;10(24):8266-74. [Content Brief]
- [4]. Wang WC, et al. [Endocrine activity of pseudolaric acids A and B and their effects on sex hormones, prostaglandins, uteri, and fetuses]. Zhongguo Yao Li Xue Bao. 1991 Mar;12(2):187-90. [Content Brief]
- [5]. Wei N, et al. The immunosuppressive activity of pseudolaric acid B on T lymphocytes in vitro. Phytother Res. 2013 Jul;27(7):980-5. [Content Brief]
