83068-69-3
83068-69-3
Chemical Structure
LK 204-545
- CAS No.: 83068-69-3
- Formula:C25H32N4O6
- Molecular Weight:484.54
IUPAC Name: 1-(2-((3-(2-cyano-4-(2-(cyclopropylmethoxy)ethoxy)phenoxy)-2-hydroxypropyl)amino)ethyl)-3-(4-hydroxyphenyl)urea
InChIKey: VAWYRUMIUGPAEX-UHFFFAOYSA-N
SMILES: O=C(NCCNCC(COC1=CC=C(C=C1C#N)OCCOCC2CC2)O)NC3=CC=C(C=C3)O
Biological Activity: LK 204-545 is a potent and highly selective β1-adrenoceptor antagonist. LK 204-545 is promising for research of cardiovascular diseases[1][2].
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LK 204-545 | LK 204-545 is a potent and highly selective β1-adrenoceptor antagonist. LK 204-545 is promising for research of cardiovascular diseases. | |||||||||||||||||||||
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References
- [1]. Louis S N S, et al. LK 204-545, a highly selective β1-adrenoceptor antagonist at human β-adrenoceptors[J]. European journal of pharmacology, 1999, 367(2-3): 431-435.
- [2]. Mistry SN, et al. Synthesis and in vitro and in vivo characterization of highly β1-selective β-adrenoceptor partial agonists. J Med Chem. 2013 May 23;56(10):3852-65. [Content Brief]
