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Cat. No.: HY-129660

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LK 204-545

LK 204-545 is a potent and highly selective β₁-adrenoceptor antagonist. LK 204-545 is promising for research of cardiovascular diseases.

For research use only. We do not sell to patients.

CAS No.: 83068-69-3
Formula: C₂₅H₃₂N₄O₆
Molecular Weight:484.54

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (263 KB)

LK 204-545 Chemical Structure

CAS No.: 83068-69-3

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

LK 204-545 is a potent and highly selective β₁-adrenoceptor antagonist. LK 204-545 is promising for research of cardiovascular diseases^[1]^[2].

All Adrenergic Receptor Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
CHO-K1	EC₅₀	10 μM Compound: 1, LK 204-545	Agonist activity at human beta2 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrs Agonist activity at human beta2 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrs	[PMID: 23614528]
CHO-K1	EC₅₀	10 μM Compound: 1, LK 204-545	Agonist activity at human beta3 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrs Agonist activity at human beta3 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrs	[PMID: 23614528]

Chemical Information

CAS No. 83068-69-3
Molecular Weight 484.54
Formula C₂₅H₃₂N₄O₆
SMILES

O=C(NCCNCC(COC1=CC=C(C=C1C#N)OCCOCC2CC2)O)NC3=CC=C(C=C3)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (263 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Louis S N S, et al. LK 204-545, a highly selective β1-adrenoceptor antagonist at human β-adrenoceptors[J]. European journal of pharmacology, 1999, 367(2-3): 431-435.

[2]. Mistry SN, et al. Synthesis and in vitro and in vivo characterization of highly β1-selective β-adrenoceptor partial agonists. J Med Chem. 2013 May 23;56(10):3852-65. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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