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Cat. No.: HY-129660

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LK 204-545

LK 204-545 is a potent and highly selective β₁-adrenoceptor antagonist. LK 204-545 is promising for research of cardiovascular diseases.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 83068-69-3
화학식: C₂₅H₃₂N₄O₆
분자량:484.54

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (263 KB)

LK 204-545 Chemical Structure

CAS No.: 83068-69-3

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

LK 204-545 is a potent and highly selective β₁-adrenoceptor antagonist. LK 204-545 is promising for research of cardiovascular diseases^[1]^[2].

All Adrenergic Receptor Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
CHO-K1	EC₅₀	10 μM Compound: 1, LK 204-545	Agonist activity at human beta2 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrs Agonist activity at human beta2 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrs	[PMID: 23614528]
CHO-K1	EC₅₀	10 μM Compound: 1, LK 204-545	Agonist activity at human beta3 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrs Agonist activity at human beta3 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrs	[PMID: 23614528]

Chemical Information

CAS No. 83068-69-3
분자량 484.54
화학식 C₂₅H₃₂N₄O₆
SMILES

O=C(NCCNCC(COC1=CC=C(C=C1C#N)OCCOCC2CC2)O)NC3=CC=C(C=C3)O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (263 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Louis S N S, et al. LK 204-545, a highly selective β1-adrenoceptor antagonist at human β-adrenoceptors[J]. European journal of pharmacology, 1999, 367(2-3): 431-435.

[2]. Mistry SN, et al. Synthesis and in vitro and in vivo characterization of highly β1-selective β-adrenoceptor partial agonists. J Med Chem. 2013 May 23;56(10):3852-65. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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