83997-75-5
Chemical Structure
Iododoxorubicin
- CAS 番号: 83997-75-5
- Formula:C27H28INO10
- Molecular Weight:653.42
IUPAC Name: (8S,10S)-10-(((2R,4S,5S,6S)-4-amino-5-iodo-6-methyltetrahydro-2H-pyran-2-yl)oxy)-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dione
InChIKey: PDQGEKGUTOTUNV-TZSSRYMLSA-N
SMILES: [H][C@]1(O[C@H]2C[C@@](CC3=C(C(C(C4=C5C(OC)=CC=C4)=O)=C(C(O)=C23)C5=O)O)(C(CO)=O)O)C[C@@H]([C@@H]([C@@H](O1)C)I)N
Biological Activity: Iododoxorubicin is a derivative of Doxorubicin (HY-15142A) and anticancer agent. Iododoxorubicin has stronger activity against Lewis lung carcinoma than Doxorubicin[1][2].
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Iododoxorubicin | Iododoxorubicin is a derivative of Doxorubicin (HY-15142A) and anticancer agent. Iododoxorubicin has stronger activity against Lewis lung carcinoma than Doxorubicin. | |||||||||||||||||||||
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- [1]. Berger I, et al. Molecular structure of the halogenated anti-cancer drug iododoxorubicin complexed with d(TGTACA) and d(CGATCG). Nucleic Acids Res. 1995 Nov 11;23(21):4488-94. [Content Brief]
- [2]. Twelves CJ, et al. Dobbs NA, Lawrence MA, Ramirez AJ, Summerhayes M, Richards MA, Towlson KE, Rubens RD. Iododoxorubicin in advanced breast cancer: a phase II evaluation of clinical activity, pharmacology and quality of life. Br J Cancer. 1994 Apr;69(4):726-31. [Content Brief]
Keywords
