86-40-8
86-40-8
Chemical Structure
Trypaflavin
- CAS No.: 86-40-8
- Formula:C14H14ClN3
- Molecular Weight:259.73
IUPAC Name: 3,6-diamino-10-methylacridin-10-ium chloride
InChIKey: KKAJSJJFBSOMGS-UHFFFAOYSA-N
SMILES: C[N+]1=C2C=C(N)C=CC2=CC3=C1C=C(N)C=C3.[Cl-]
Biological Activity: Trypaflavin is an acridine compound and antimalarial agent. Trypaflavin invades germ cells. Trypaflavin induces aberrations in unfertilized oocytes. Trypaflavin increases the frequency of chromosomal aberrations. Trypaflavin shows weak mutagenicity. Trypaflavin is highly toxic to Leishmania, causing immediate lysis of the leptomonads[1][2].
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Trypaflavin | Trypaflavin is an acridine compound and antimalarial agent. Trypaflavin invades germ cells. Trypaflavin induces aberrations in unfertilized oocytes. Trypaflavin increases the frequency of chromosomal aberrations. Trypaflavin shows weak mutagenicity. Trypaflavin is highly toxic to Leishmania, causing immediate lysis of the leptomonads. | |||||||||||||||||||||
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References
- [1]. Basler A, et al. Comparative investigations with trypaflavin in metaphase-II oocytes and in dominant lethal assay. Hum Genet. 1977 Dec 29;40(1):87-92. [Content Brief]
- [2]. Senekji H A. The effect of sulfanilamide and trypaflavin on cultures of Leishmania tropica. Journal of Infectious Diseases, 1940, 66(2): 111-112.
Keywords
