861038-72-4
Chemical Structure
A2764 dihydrochloride
- CAS No.: 861038-72-4
- Formula:C15H21Cl3N2O
- Molecular Weight:351.70
IUPAC Name: 2-((5-chloroquinolin-8-yl)oxy)-N,N-diethylethan-1-amine dihydrochloride
InChIKey: ZVRDPULCSHGKBD-UHFFFAOYSA-N
SMILES: ClC1=C2C=CC=NC2=C(OCCN(CC)CC)C=C1.[H]Cl.[H]Cl
Biological Activity: A2764 dihydrochloride is a highly selective inhibitor of TRESK (TWIK-related spinal cord K+ channel, K2P18.1), which has moderate inhibitory effects on TREK-1 and TALK-1. A2764 dihydrochloride is more sensitive to the activated mTRESK channels (IC50=6.8 μM) than the basal current. A2764 dihydrochloride can lead to cell depolarization and increased excitability in native cells, it has the potential for probing the role of TRESK channel in migraine and nociception[1].
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A2764 dihydrochloride | 99.05% | A2764 dihydrochloride is a highly selective inhibitor of TRESK (TWIK-related spinal cord K+ channel, K2P18.1), which has moderate inhibitory effects on TREK-1 and TALK-1. A2764 dihydrochloride is more sensitive to the activated mTRESK channels (IC50=6.8 μM) than the basal current. A2764 dihydrochloride can lead to cell depolarization and increased excitability in native cells, it has the potential for probing the role of TRESK channel in migraine and nociception. | ||||||||||||||||||||
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Keywords
