86482-18-0
Chemical Structure
Augpenin
Synonym(s): Ticarcillin-clavulanic acid mixt.; BRL28500
- CAS No.: 86482-18-0
- Formula:C23H25N3O11S2
- Molecular Weight:583.59
InChIKey: XWMVMWTVLSLJGY-FAJPTIRJSA-N
SMILES: OC([C@H](C1=CSC=C1)C(N[C@H]2[C@]3([H])N(C2=O)[C@H](C(C)(S3)C)C(O)=O)=O)=O.OC([C@@H]4N5[C@](CC5=O)([H])O/C4=C\CO)=O
Biological Activity: Augpenin (Ticarcillin-clavulanic acid mixt.; BRL28500) is a compound β-lactam antibacterial mixture of Ticarcillin (HY-139805) and Clavulanic acid (HY-A0256) in a 15:1 ratio. Ticarcillin in Augpenin acts on bacterial penicillin-binding proteins, while Clavulanic acid acts as an irreversible β-lactamase inhibitor that protects Ticarcillin from hydrolysis and restores its inhibitory activity against resistant strains. Augpenin significantly reduces the bacterial load of Legionella pneumophila in lung tissue of Cyclophosphamide (HY-17420)-induced neutropenic young rats. Augpenin can be used in research related to bacterial infections[1][2][3].
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Augpenin | Augpenin (Ticarcillin-clavulanic acid mixt.; BRL28500) is a compound β-lactam antibacterial mixture of Ticarcillin (HY-139805) and Clavulanic acid (HY-A0256) in a 15:1 ratio. Ticarcillin in Augpenin acts on bacterial penicillin-binding proteins, while Clavulanic acid acts as an irreversible β-lactamase inhibitor that protects Ticarcillin from hydrolysis and restores its inhibitory activity against resistant strains. Augpenin significantly reduces the bacterial load of Legionella pneumophila in lung tissue of Cyclophosphamide (HY-17420)-induced neutropenic young rats. Augpenin can be used in research related to bacterial infections. | |||||||||||||||||||||
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References
- [1]. Itokazu GS, et al. Ampicillin-sulbactam and ticarcillin-clavulanic acid: a comparison of their in vitro activity and review of their clinical efficacy. Pharmacotherapy. 1991;11(5):382-414.
- [2]. Kasai T, et al. The antibacterial activity of ticarcillin/clavulanic acid (BRL28500) against ticarcillin-resistant bacteria. The Journal of antibiotics. 1986 Oct;39(10):1450-60.
- [3]. Smith GM, et al. Bactericidal effects of ticarcillin-clavulanic acid against Legionella pneumophila pneumonia in immunocompromised weanling rats. Antimicrobial agents and chemotherapy. 1991 Jul;35(7):1423-9.
