88899-56-3
Chemical Structure
Bafilomycin B1
- CAS No.: 88899-56-3
- Formula:C44H65NO13
- Molecular Weight:815.99
IUPAC Name: (2R,4R,5S,6R)-2-hydroxy-2-((2S,3R,4S)-3-hydroxy-4-((2R,3S,4E,6E,9S,10S,11R,12E,14Z)-10-hydroxy-3,15-dimethoxy-7,9,11,13-tetramethyl-16-oxooxacyclohexadeca-4,6,12,14-tetraen-2-yl)pentan-2-yl)-6-isopropyl-5-methyltetrahydro-2H-pyran-4-yl (E)-4-((2-hydroxy-5-oxocyclopent-1-en-1-yl)amino)-4-oxobut-2-enoate
InChIKey: KFUFLYSBMNNJTF-ANDWMEETSA-N
SMILES: O=C(O[C@@H]1C[C@@]([C@@H](C)[C@H](O)[C@@H]([C@H]([C@@H](OC)/C=C/C=C(C)/C[C@H](C)[C@H](O)[C@H](C)/C=C(C)/C=C2\OC)OC2=O)C)(O)O[C@H](C(C)C)[C@H]1C)/C=C/C(NC3=C(O)CCC3=O)=O
Biological Activity: Bafilomycin B1 is a macrolide antibiotic that can be isolated from mycelium of Streptomyces gresuis. Bafilomycin B1 is neuroprotective against Chloroquine (HY-17589A)-induced death. Bafilomycin B1 is a structural analog of Bafilomycin A1 and has the ability to inhibit V-ATPase. Bafilomycin B1 inhibits significantly the oxidized low density lipoprotein (LDL)-induced accumulation of lipid droplets[1][2][3].
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Bafilomycin B1 | 98.10% | Bafilomycin B1 is a macrolide antibiotic that can be isolated from mycelium of Streptomyces gresuis. Bafilomycin B1 is neuroprotective against Chloroquine (HY-17589A)-induced death. Bafilomycin B1 is a structural analog of Bafilomycin A1 and has the ability to inhibit V-ATPase. Bafilomycin B1 inhibits significantly the oxidized low density lipoprotein (LDL)-induced accumulation of lipid droplets. | ||||||||||||||||||||
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- [1]. Shacka, J. J., et al., (2006). Autophagy, bafilomycin and cell death: the "a-B-cs" of plecomacrolide-induced neuroprotection. Autophagy, 2(3), 228–230. [Content Brief]
- [2]. Pivtoraiko, V. N., et al., (2010). Low-dose bafilomycin attenuates neuronal cell death associated with autophagy-lysosome pathway dysfunction. Journal of neurochemistry, 114(4), 1193–1204. [Content Brief]
- [3]. Naganuma, S., et al., (1992). Inhibition of the accumulation of lipid droplets in macrophage J774 by bafilomycin B1 and destruxin E. Biochimica et biophysica acta, 1126(1), 41–48. [Content Brief]
Keywords
