892128-60-8
892128-60-8
Chemical Structure
LY2334737
- No. CAS: 892128-60-8
- Formula:C17H25F2N3O5
- Molecular Weight:389.39
IUPAC Name: N-(1-((2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)-2-propylpentanamide
InChIKey: MEOYFIHNRBNEPI-UXIGCNINSA-N
SMILES: OC[C@@H]1[C@H](C(F)(F)[C@H](N2C(N=C(C=C2)NC(C(CCC)CCC)=O)=O)O1)O
Biological Activity: LY2334737 is an nucleoside analog and is an orally active proagent of Gemcitabine. LY2334737 exhibits inhibitory activity against enterovirus A71 (EV-A71) infection. LY2334737 has antiviral and anticancer effects[1][2].
| Referencia número | Nombre del producto | Pureza | Descripciòn | Pricing | |||||||||||||||||||
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LY2334737 | 98.55% | LY2334737 is an nucleoside analog and is an orally active proagent of Gemcitabine. LY2334737 exhibits inhibitory activity against enterovirus A71 (EV-A71) infection. LY2334737 has antiviral and anticancer effects. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.75
HY-185323Gem-C12 -
Similarity Score 0.72
HY-150722HDAC6-IN-12 -
Similarity Score 0.68
HY-154843C-Gem -
Similarity Score 0.67
HY-154842S-Gem -
Similarity Score 0.67
HY-B0003A1'-epi Gemcitabine hydrochloride -
Similarity Score 0.67
HY-B0003AS(2S)-Gemcitabine-13C,15N2 hydrochloride -
Similarity Score 0.67
HY-B0003RGemcitabine hydrochloride (Standard) -
Similarity Score 0.67
HY-B0003SGemcitabine-13C,15N2 hydrochloride -
Similarity Score 0.67
HY-17026Gemcitabine -
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References
- [1]. Pratt SE, et al. Human carboxylesterase-2 hydrolyzes the prodrug of gemcitabine (LY2334737) and confers prodrug sensitivity to cancer cells. Clin Cancer Res. 2013 Mar 1;19(5):1159-68. [Content Brief]
- [2]. Jialei Sun, et al. Drug Repurposing of Pyrimidine Analogs as Potent Antiviral Compounds Against Human Enterovirus A71 Infection With Potential Clinical Applications. Sci Rep. 2020 May 18;10(1):8159. [Content Brief]
