894002-50-7
894002-50-7
Chemical Structure
LDN-212320
Synonym(s): LDN-0212320; OSU-0212320
- CAS No.: 894002-50-7
- Formula:C17H15N3S
- Molecular Weight:293.39
IUPAC Name: 3-((2-methylbenzyl)thio)-6-(pyridin-2-yl)pyridazine
InChIKey: DUUQLWDHNYFUPP-UHFFFAOYSA-N
SMILES: CC1=CC=CC=C1CSC2=NN=C(C3=NC=CC=C3)C=C2
Biological Activity: LDN-212320 (LDN-0212320) is a glutamate transporter (GLT-1)/excitatory amino acid transporter 2 (EAAT2) activator (at translational level). LDN-212320 (LDN-0212320) prevents nociceptive pain by upregulating astroglial GLT-1 expression in the hippocampus and ACC[1][2].
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LDN-212320 | 98.92% | LDN-212320 (LDN-0212320) is a glutamate transporter (GLT-1)/excitatory amino acid transporter 2 (EAAT2) activator (at translational level). LDN-212320 (LDN-0212320) prevents nociceptive pain by upregulating astroglial GLT-1 expression in the hippocampus and ACC
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Structural Analogs
-
Similarity Score 0.77
HY-139692EAAT2 activator 1 -
Similarity Score 0.63
HY-W2506724'-Methyl-2,2':6',2''-terpyridine -
Similarity Score 0.63
HY-W0384143,5-Di(2-pyridyl)pyrazole -
Similarity Score 0.62
HY-W1126242,5-Di(pyridin-2-yl)-1H-pyrrole -
Similarity Score 0.62
![[2,2':6',2''-Terpyridin]-4'-ol Chemical Structure](//file.medchemexpress.com/product_pic/hy-w081679.gif)
HY-W081679[2,2':6',2''-Terpyridin]-4'-ol -
Similarity Score 0.62
![[2,2':6',2''-terpyridine]-4'-carbaldehyde Chemical Structure](//file.medchemexpress.com/product_pic/hy-w075051.gif)
HY-W075051[2,2':6',2''-terpyridine]-4'-carbaldehyde -
Similarity Score 0.62
HY-W0045864'-Chloro-2,2':6',2''-terpyridine -
Similarity Score 0.62
HY-W0045934'-Bromo-2,2':6',2''-terpyridine -
Similarity Score 0.61
![6-Phenyl-[2,2'-bipyridine]-4-carboxylic acid Chemical Structure](//file.medchemexpress.com/product_pic/hy-w873898.gif)
HY-W8738986-Phenyl-[2,2'-bipyridine]-4-carboxylic acid -
Explore the MedChemAI to find more analogs
![[2,2':6',2''-Terpyridin]-4'-ol Chemical Structure](http://file.medchemexpress.com/product_pic/hy-w081679.gif)
![[2,2':6',2''-terpyridine]-4'-carbaldehyde Chemical Structure](http://file.medchemexpress.com/product_pic/hy-w075051.gif)
![6-Phenyl-[2,2'-bipyridine]-4-carboxylic acid Chemical Structure](http://file.medchemexpress.com/product_pic/hy-w873898.gif)
