90-47-1
90-47-1
Chemical Structure
Xanthone
- CAS No.: 90-47-1
- Formula:C13H8O2
- Molecular Weight:196.21
IUPAC Name: 9H-xanthen-9-one
InChIKey: JNELGWHKGNBSMD-UHFFFAOYSA-N
SMILES: O=C1C2=C(OC3=C1C=CC=C3)C=CC=C2
Biological Activity: Xanthone is a monoamine oxidase A (MAO-A) inhibitor with an IC50 of 0.84 µM. Xanthon inhibits Norepinephrine (HY-13715) and high-K+-induced vasoconstriction with IC50 values of 60.26 μM and 82.9 μM, respectively. Xanthon increases intracellular cyclic adenosine 3′,5′-monophosphate (cAMP) content and blocks Ca2+ channels. Xanthone is the scaffold of several pharmacologically active compounds[1][2].
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Xanthone | 99.97% | Xanthone is a monoamine oxidase A (MAO-A) inhibitor with an IC50 of 0.84 µM. Xanthon inhibits Norepinephrine (HY-13715) and high-K+-induced vasoconstriction with IC50 values of 60.26 μM and 82.9 μM, respectively. Xanthon increases intracellular cyclic adenosine 3′,5′-monophosphate (cAMP) content and blocks Ca2+ channels. Xanthone is the scaffold of several pharmacologically active compounds. | ||||||||||||||||||||
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Xanthone (Standard) | 99.99% | Xanthone (Standard) is the analytical standard of Xanthone (HY-N0126). This product is intended for research and analytical applications. Xanthone is a monoamine oxidase A (MAO-A) inhibitor with an IC50 of 0.84 µM. Xanthon inhibits Norepinephrine (HY-13715) and high-K+-induced vasoconstriction with IC50 values of 60.26 μM and 82.9 μM, respectively. Xanthon increases intracellular cyclic adenosine 3′,5′-monophosphate (cAMP) content and blocks Ca2+ channels. Xanthone is the scaffold of several pharmacologically active compounds. | ||||||||||||||||||||
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References
- [1]. Cheng YW, et al. Mechanism of vasorelaxation of thoracic aorta caused by xanthone. Eur J Pharmacol. 1997 Oct 1;336(1):23-8. [Content Brief]
- [2]. El-Seedi HR, et al. Recent insights into the biosynthesis and biological activities of natural xanthones. Curr Med Chem. 2010;17(9):854-901. [Content Brief]
