90-98-2
90-98-2
Chemical Structure
4,4'-Dichlorobenzophenone
Synonym(s): Bis(4-chlorophenyl) ketone
- CAS No.: 90-98-2
- Formula:C13H8Cl2O
- Molecular Weight:251.11
IUPAC Name: bis(4-chlorophenyl)methanone
InChIKey: OKISUZLXOYGIFP-UHFFFAOYSA-N
SMILES: ClC1=CC=C(C(C2=CC=C(Cl)C=C2)=O)C=C1
Biological Activity: 4,4'-Dichlorobenzophenone (Bis (4-chlorophenyl) ketone) is an ERα/ERβ agonist with IC50 values of 40.86 μM and 24.11 μM, respectively. 4,4'-Dichlorobenzophenone induces ER-dependent cancer cell proliferation after long-term exposure. 4,4'-Dichlorobenzophenone can be used for research on breast cancer[1][2][3][4].
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4,4'-Dichlorobenzophenone | 99.93% | 4,4'-Dichlorobenzophenone (Bis (4-chlorophenyl) ketone) is an ERα/ERβ agonist with IC50 values of 40.86 μM and 24.11 μM, respectively. 4,4'-Dichlorobenzophenone induces ER-dependent cancer cell proliferation after long-term exposure. 4,4'-Dichlorobenzophenone can be used for research on breast cancer. | ||||||||||||||||||||
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References
- [1]. Ivorra L, et al. Environmental characterization of 4,4'-dichlorobenzophenone in surface waters from Macao and Hong Kong coastal areas (Pearl River Delta) and its toxicity on two biological models: Artemia salina and Daphnia magna. Ecotoxicology and environmental safety. 2019 Apr 30;171:1-11.
- [2]. Wang L, et al. Comparative in vitro and in silico study on the estrogenic effects of 2,2-bis(4-chlorophenyl)ethanol, 4,4'-dichlorobenzophenone and DDT analogs. The Science of the total environment. 2023 Jun 10;876:162734.
- [3]. Ivorra L, et al. Uptake and depuration kinetics of dicofol metabolite 4,4'-dichlorobenzophenone, in the edible Asiatic clam Meretrix meretrix. Chemosphere. 2019 Nov;235:662-669.
- [4]. Yoneyama K, et al. Reductive metabolism of heptachlor, parathion, 4, 4′-dichlorobenzophenone, and carbophenothion by rat liver systems. Pesticide Biochemistry and Physiology. 1981 Jun 1;15(3):213-21.
