936498-64-5
Chemical Structure
ICL-CCIC-0019
- CAS No.: 936498-64-5
- Formula:C26H44Br2N4
- Molecular Weight:572.46
IUPAC Name: 1,1'-(dodecane-1,12-diyl)bis(4-(dimethylamino)pyridin-1-ium) bromide
InChIKey: SRYRXSJEWKGQSC-UHFFFAOYSA-L
SMILES: CN(C)C1=CC=[N+](C=C1)CCCCCCCCCCCC[N+]2=CC=C(C=C2)N(C)C.[Br-].[Br-]
Biological Activity: ICL-CCIC-0019 is a CHKA inhibitor with a human IC50 of 270 nM. ICL-CCIC-0019 blocks choline phosphorylation and phosphatidylcholine synthesis via the CDP-choline pathway. ICL-CCIC-0019 inhibits choline uptake, mitochondrial respiration, TCA cycle flux, de novo fatty acid synthesis, and mitochondrial membrane potential, while inducing G1 phase arrest, ER stress, caspase-dependent apoptosis, AMPK activation, glycolysis, acetate uptake, and mitochondrial network disruption. ICL-CCIC-0019 can be used for cancer research[1][2].
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ICL-CCIC-0019 | 97.80% | ICL-CCIC-0019 is a CHKA inhibitor with a human IC50 of 270 nM. ICL-CCIC-0019 blocks choline phosphorylation and phosphatidylcholine synthesis via the CDP-choline pathway. ICL-CCIC-0019 inhibits choline uptake, mitochondrial respiration, TCA cycle flux, de novo fatty acid synthesis, and mitochondrial membrane potential, while inducing G1 phase arrest, ER stress, caspase-dependent apoptosis, AMPK activation, glycolysis, acetate uptake, and mitochondrial network disruption. ICL-CCIC-0019 can be used for cancer research. | ||||||||||||||||||||
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Similarity Score 0.71
HY-101237RDHBP dibromide (Standard) -
Similarity Score 0.68
HY-107674bPiDDB -
Similarity Score 0.67
HY-W1650851,10-Bis(pyridinium)decane -
Similarity Score 0.64
HY-152170bPiDI -
Similarity Score 0.61
HY-D121110-Dodecylacridine Orange Bromide -
Similarity Score 0.60
HY-W011038Hexadecylpyridinium bromide -
Similarity Score 0.60
HY-B1289Cetylpyridinium chloride monohydrate -
Similarity Score 0.59
HY-B1464RCetylpyridinium chloride (Standard) -
Similarity Score 0.59
HY-111405Antimicrobial Compound 1 -
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References
- [1]. Wang N, et al. Novel Non-Congeneric Derivatives of the Choline Kinase Alpha Inhibitor ICL-CCIC-0019. Pharmaceutics. 2021 Jul 14;13(7):1078.
- [2]. Trousil S, et al. The novel choline kinase inhibitor ICL-CCIC-0019 reprograms cellular metabolism and inhibits cancer cell growth. Oncotarget. 2016 Jun 14;7(24):37103-37120. [Content Brief]
