94159-47-4
94159-47-4
Chemical Structure
3-sucCA
Synonym(s): 3-Succinylated cholic acid
- CAS No.: 94159-47-4
- Formula:C28H44O8
- Molecular Weight:508.64
InChIKey: HCNXRYWFDFDKOR-NLLMDGPUSA-N
SMILES: O[C@H]1[C@@]2([H])[C@@]3([H])[C@@]([C@@](CC3)([H])[C@H](C)CCC(O)=O)([C@H](C[C@]2([H])[C@@]4([C@](C[C@@H](CC4)OC(CCC(O)=O)=O)([H])C1)C)O)C
Biological Activity: 3-sucCA is an orally available bacterial bile acid that exerts anti-MASH effects by promoting the growth of Akkermansia muciniphila. By remodeling the intestinal microbiota and promoting the growth of Akkermansia, 3-sucCA can improve intestinal barrier damage and reduce chronic low-level inflammation, thereby alleviating the progression of metabolic dysfunction-associated steatohepatitis (MASH). 3-sucCA accelerates the synthesis of cell wall peptidoglycan and has in vivo efficacy in the mouse MAFL-MASH model. 3-sucCA levels are low in the MAFLD model and are mainly used in the study of MASH[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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3-sucCA | 99.92% | 3-sucCA is an orally available bacterial bile acid that exerts anti-MASH effects by promoting the growth of Akkermansia muciniphila. By remodeling the intestinal microbiota and promoting the growth of Akkermansia, 3-sucCA can improve intestinal barrier damage and reduce chronic low-level inflammation, thereby alleviating the progression of metabolic dysfunction-associated steatohepatitis (MASH). 3-sucCA accelerates the synthesis of cell wall peptidoglycan and has in vivo efficacy in the mouse MAFL-MASH model. 3-sucCA levels are low in the MAFLD model and are mainly used in the study of MASH. | ||||||||||||||||||||
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Methyl cholate | 99.81% | Methyl cholate is a bile acid analog and a specific inhibitor of TcdB toxin from Clostridioides difficile. Methyl cholate exerts a stronger selective inhibitory effect on TcdB than on TcdA. Methyl cholate induces conformational stabilization by binding to a unique site of TcdB, thereby blocking the binding of the toxin to host receptors and its self-processing process. Methyl cholate effectively protects human fibroblasts from TcdB-induced cytopathic effects. Methyl cholate exhibits dose-dependent anti-hepatic fibrosis activity in both cellular and zebrafish models, and significantly reduces the expression levels of α-SMA and COL-I. Methyl cholate is suitable for in-depth research in the fields of Clostridioides difficile infection and hepatic fibrosis. | ||||||||||||||||||||
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Ursocholic acid (Standard) | ≥98% | Ursocholic acid (Standard) is the analytical standard of Ursocholic acid. This product is intended for research and analytical applications. Ursocholic acid, a bile acid present in mammalian bile, is converted to deoxycholic acid (UDC) by the mouse intestinal flora. Ursocholic acid acts as a gallstone dissolving agent in the liver through anti-apoptosis, anti-inflammatory, immunomodulatory, bile regulation, and coordinated changes in mitochondrial integrity and cell signaling, Ursocholic acid also has favorable effects on bones in patients with chronic cholestasis. | ||||||||||||||||||||
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Allocholic acid | Allocholic acid is a typically fetal bile acid found in vertebrates and reappears during liver regeneration and carcinogenesis, besides it is also a conjugate acid of allocholate and an isomer of cholic acid. Allocholic acid is a potent and specific stimulant of the adult olfactory system, it has a role as a marine metabolite, a rat metabolite and a human metabolite. | |||||||||||||||||||||
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Homocholic acid | Homocholic acid is a synthetic steroid analogue. Homocholic acid can be labeled with 75Se and is used for SeHCAT detection (a method for diagnosing bile acid malabsorption). | |||||||||||||||||||||
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Cholic acid | 99.80% | Cholic acid is a major primary bile acid produced in the liver and usually conjugated with glycine or taurine. It facilitates fat absorption and cholesterol excretion. Cholic acid is orally active. | ||||||||||||||||||||
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Cholic acid-13C | 99.17% | Cholic acid-13C is the 13C-labeled Cholic acid. Cholic acid is a major primary bile acid produced in the liver and usually conjugated with glycine or taurine. It facilitates fat absorption and cholesterol excretion. | ||||||||||||||||||||
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3-Oxocholic acid (Standard) | ≥98% | 3-?Oxocholic acid (Standard) (3-Dehydrocholic acid (Standard)) is the analytical standard of 3-?Oxocholic acid (HY-N7387). This product is intended for research and analytical applications. 3-Oxocholic acid is an oxo-bile acid metabolite and also a major degradation product from cholic by C. perfringens in the intestine. 3-Oxocholic acid is steroid acid found predominantly in bile of mammals. | ||||||||||||||||||||
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Isodeoxycholic acid (Standard) | ≥98% | Isodeoxycholic acid (7α,12α-Dihydroxycholanoic acid) Standard is the analytical standard of Isodeoxycholic acid (HY-W399297). This product is intended for research and analytical applications. Isodeoxycholic acid (7α,12α-Dihydroxycholanoic acid) is a 3β-hydroxylated secondary bile acid. Isodeoxycholic acid is produced by epimerization of deoxycholic acid by intestinal bacteria. Isodeoxycholic acid is detectable in feces, mainly existing as saponifiable conjugates with long-chain fatty acids. Isodeoxycholic acid participates in the regulation of intestinal physiology. | ||||||||||||||||||||
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3β-Cholic acid | 99.7% | 3β-Cholic acid is a derivative of cholic acid (HY-N0324), and can be found in human feces. | ||||||||||||||||||||
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12β-Hydroxyisocholic acid | 99.66% | 12β-Hydroxyisocholic acid (Lagocholic acid) is a bile acid isomer that can be used in the study of bile acid metabolism. | ||||||||||||||||||||
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References
- [1]. Nie Q, et al. Gut symbionts alleviate MASH through a secondary bile acid biosynthetic pathway. Cell. 2024 May 23;187(11):2717-2734.e33. [Content Brief]
- [2]. Chang S, et al. Succinate supplementation alleviates liver cancer by inhibiting the FN1/SQLE axis-mediated cholesterol biosynthesis. iScience. 2025 Jan 2;28(2):111731. [Content Brief]
