97852-72-7
Chemical Structure
Tibenelast free acid
Synonym(s): LY186655 free acid
- CAS No.: 97852-72-7
- Formula:C13H14O4S
- Molecular Weight:266.31
IUPAC Name: 5,6-diethoxybenzo[b]thiophene-2-carboxylic acid
InChIKey: PDUXMHXBBXXJFQ-UHFFFAOYSA-N
SMILES: O=C(C1=CC2=C(C=C(C(OCC)=C2)OCC)S1)O
Biological Activity: Tibenelast (LY186655) free acid is a potent and orally active is a phosphodiesterase inhibitor. Tibenelast free acid is an anti-asthma agent Tibenelast free acid increases the heart rate response to isoproterenol (HY-108353). Tibenelast free acid shows anti-anaphylactic shock activity. Tibenelast free acid has the potential for the research of asthma and other respiratory diseases[1][2].
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Tibenelast free acid | Tibenelast (LY186655) free acid is a potent and orally active is a phosphodiesterase inhibitor. Tibenelast free acid is an anti-asthma agent Tibenelast free acid increases the heart rate response to isoproterenol (HY-108353). Tibenelast free acid shows anti-anaphylactic shock activity. Tibenelast free acid has the potential for the research of asthma and other respiratory diseases. | |||||||||||||||||||||
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References
- [1]. Ho PP, et al. Tibenelast, 5,6-diethoxybenzo(B)thiophene-2-carboxylic acid, sodium salt (LY186655), is an orally active anti-asthma compound in the guinea pig. Life Sci. 1990;46(13):917-25. [Content Brief]
- [2]. Schwertschlag US, et al. Effect of tibenelast (a phosphodiesterase inhibitor) and theophylline on isoproterenol-stimulated heart rate, cyclic AMP and norepinephrine levels. Pharmacology. 1993;46(3):142-7. [Content Brief]
