99-83-2
Chemical Structure
α-Phellandrene
Synonym(s): alpha-Phellandrene
- CAS No.: 99-83-2
- Formula:C10H16
- Molecular Weight:136.23
IUPAC Name: 5-isopropyl-2-methylcyclohexa-1,3-diene
InChIKey: OGLDWXZKYODSOB-UHFFFAOYSA-N
SMILES: CC1=CCC(C=C1)C(C)C
Biological Activity: α-Phellandrene (alpha-Phellandrene) is an orally active monoterpenoid and insecticide. α-Phellandrene can be isolated from plant essential oils. α-Phellandrene induces Apoptosis and Autophagy. α-Phellandrene promotes cAMP signaling pathway and increases NO production. α-Phellandrene has anti-inflammatory and anticancer (sarcoma) activities. α-Phellandrene shows insecticidal activity against Lucilia cuprina L3. α-Phellandrene reduces mechanical hyperalgesia[1][2][3][4][5][6][7][8][9][10][11].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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α-Phellandrene | 85.70% | α-Phellandrene (alpha-Phellandrene) is an orally active monoterpenoid and insecticide. α-Phellandrene can be isolated from plant essential oils. α-Phellandrene induces Apoptosis and Autophagy. α-Phellandrene promotes cAMP signaling pathway and increases NO production. α-Phellandrene has anti-inflammatory and anticancer (sarcoma) activities. α-Phellandrene shows insecticidal activity against Lucilia cuprina L3. α-Phellandrene reduces mechanical hyperalgesia. | ||||||||||||||||||||
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References
- [1]. Abdouli I, et al. TiO2 Catalyzed Dihydroxyacetone (DHA) Conversion in Water: Evidence That This Model Reaction Probes Basicity in Addition to Acidity. Molecules. 2022 Nov 24;27(23):8172. [Content Brief]
- [2]. Susanto AC, et al. α‑Phellandrene enhances the apoptosis of HT‑29 cells induced by 5‑fluorouracil by modulating the mitochondria‑dependent pathway. Oncol Rep. 2024 Apr;51(4):61. [Content Brief]
- [3]. Hsieh SL, et al. Induction of necrosis in human liver tumor cells by α-phellandrene. Nutr Cancer. 2014;66(6):970-9. [Content Brief]
- [4]. Lin JJ, et al. α-Phellandrene alters expression of genes associated with DNA damage, cell cycle, and apoptosis in murine leukemia WEHI-3 cells. Anticancer Res. 2014 Aug;34(8):4161-80. [Content Brief]
- [5]. Kang W, et al. Activation of cAMP Signaling in Response to α-Phellandrene Promotes Vascular Endothelial Growth Factor Levels and Proliferation in Human Dermal Papilla Cells. Int J Mol Sci. 2022 Aug 11;23(16):8959. [Content Brief]
- [6]. Hsieh LC, et al. Induction of α-phellandrene on autophagy in human liver tumor cells. Am J Chin Med. 2015;43(1):121-36. [Content Brief]
- [7]. Chaaban A, et al. Insecticide activity of Curcuma longa (leaves) essential oil and its major compound α-phellandrene against Lucilia cuprina larvae (Diptera: Calliphoridae): Histological and ultrastructural biomarkers assessment. Pestic Biochem Physiol. 2019 Jan;153:17-27. [Content Brief]
- [8]. Lin JJ, et al. Alpha-phellandrene promotes immune responses in normal mice through enhancing macrophage phagocytosis and natural killer cell activities. In Vivo. 2013 Nov-Dec;27(6):809-14. [Content Brief]
- [9]. Pinheiro-Neto FR, et al. α-Phellandrene exhibits antinociceptive and tumor-reducing effects in a mouse model of oncologic pain. Toxicol Appl Pharmacol. 2021 May 1;418:115497. [Content Brief]
- [10]. Gonçalves R L G, et al. α-Phellandrene attenuates tissular damage, oxidative stress, and TNF-α levels on acute model ifosfamide-induced hemorrhagic cystitis in mice. Naunyn-Schmiedeberg's Archives of Pharmacology, 2020, 393: 1835-1848.
- [11]. Siqueira HDS, et al. α-Phellandrene, a cyclic monoterpene, attenuates inflammatory response through neutrophil migration inhibition and mast cell degranulation. Life Sci. 2016 Sep 1;160:27-33. [Content Brief]
