2. Cell Cycle/DNA Damage
  3. CDK
  4. CDK7-IN-27

CDK7-IN-27 (Compound 37) is a selective inhibitor for cyclin-dependent kinase 7 (CDK7), with Ki of 3 nM. CDK7-IN-27 arrests the cell cycle at G0/G1 phase.

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CDK7-IN-27

CDK7-IN-27 構造式

CAS 番号 : 3025006-89-4

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CDK7-IN-27 関連抗体

Top Publications Citing Use of Products

CDK アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85 CDK10 CDK15 CDK17 CDK18 CDK20 PITSLRE

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製品説明

CDK7-IN-27 (Compound 37) is a selective inhibitor for cyclin-dependent kinase 7 (CDK7), with Ki of 3 nM. CDK7-IN-27 arrests the cell cycle at G0/G1 phase[1].

IC50 & Target

CDK7

3 nM (IC50)

CDK2

19.4 nM (IC50)

Cellular Effect
Cell Line Type Value Description References
MDA-MB-453 EC50
1.49 μM
Compound: 37
Antiproliferative activity against human MDA-MB-453 cells assessed as reduction in cell viability incubated for 5 days by CCK-8 assay
Antiproliferative activity against human MDA-MB-453 cells assessed as reduction in cell viability incubated for 5 days by CCK-8 assay
[PMID: 38586950]
体外実験

CDK7-IN-27 (0.04-10 μM, 5 days) inhibits proliferations of MDA-MB-453 cells with EC50 of 1.49 μM[1].
CDK7_IN-27 (1 μM, 24 h) exhibits good metabolic stability in liver microsomes in mouse and human , with a half-time of 38.5 min and 34.1 min[1].
CDK7_IN-27 (0-1 μM, 24 h) suppresses the phosphorylation of retinoblastoma (Rb) protein through CDK7 inhibition, and thus arrests the cell cycle at G0/G1 phase[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CDK7-IN-27 関連抗体

Western Blot Analysis[1]

Cell Line: MDA-MB-453
Concentration: 0-1 μM
Incubation Time: 24 h
Result: Inhibited phosphorylation of Rb protein at Ser780, 807/811, and Thr826.

Cell Viability Assay[1]

Cell Line: MDA-MB-453
Concentration: 0.04-10 μM
Incubation Time: 5 days
Result: Suppressed the cancer cell proliferation.
分子量

479.62

分子式

C26H37N7O2
CAS 番号
SMILES

CC(C1=C2N=C3N=C(N2N=C1)NCC4=CC=CC=C4OC[C@H](CCCC5(CN3)CCNCC5)O)C
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
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CDK7-IN-27 Related Classifications

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    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CDK7-IN-273025006-89-4CDKCyclin dependent kinaseMDA-MB-453TNBCtriple-negative breast cancerInhibitorinhibitorinhibit

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製品名:
CDK7-IN-27
製品番号:
HY-162416
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